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CONTEXT The percentage of free prostate-specific antigen (PSA) in serum has been shown to enhance the specificity of PSA testing for prostate cancer detection, but earlier studies provided only preliminary cutoffs for clinical use. OBJECTIVE To develop risk assessment guidelines and a cutoff value for defining abnormal percentage of free PSA in a(More)
OBJECTIVES In predominately white populations, measurement of the percentage of free prostate-specific antigen (%fPSA) has been shown to enhance the specificity of total PSA testing for prostate cancer while maintaining high sensitivity and to aid in prostate cancer staging. This study evaluated whether the %fPSA cutoff that maintained a 95% sensitivity in(More)
The aim of this study was to assess the ability of serum bone-specific alkaline phosphatase (bone ALP), creatinine-corrected urinary collagen crosslinks (CTx) and calcaneus bone mineral density (BMD) to identify postmenopausal women who have an increased risk of osteoporotic fractures. Calcaneus BMD and biochemical markers of bone turnover (serum bone ALP(More)
The principal constituent of amyloid plaques found in the brains of individuals with Alzheimer's disease (AD) is a 39-42-amino-acid protein, amyloid beta protein (A beta). This study examined whether the measurement of A beta levels in CSF has diagnostic value. There were 108 subjects enrolled in this prospective study: AD (n = 39), non-AD controls(More)
PURPOSE Prostate specific antigen (PSA) exists in bound (complexed) and unbound (free) forms in serum. The percentage of free PSA enhances the specificity of PSA testing for prostate cancer detection. We evaluated the use of percent free PSA preoperatively to predict pathological stage. MATERIALS AND METHODS A total of 379 men with prostate cancer and 394(More)
PURPOSE We evaluated the daily biological variation of serum prostate specific antigen (PSA) concentrations to determine the critical difference required between 2 consecutive PSA measurements that would indicate a significant elevation. MATERIALS AND METHODS A total of 24 men, grouped according to clinical diagnosis and PSA, underwent phlebotomy for 10(More)
Recently there has been discussion about the metabolic state of the ocean, with arguments questioning whether the open ocean is net autotrophic or net heterotrophic. Accurately determining the metabolic balance of a marine system depends on fully defining the system being evaluated and on quantifying the inputs and outputs to that system. Here, a net(More)
We simulate and interpret the photodissociation and recombination of I 2-embedded in CO 2 clusters using a Hamiltonian that accounts for the strong perturbation of the solute electronic structure by the solvent. The calculated product distributions agree well with the experimental results of Lineberger and co-workers. Excited-state dynamics are more(More)
Combining an effective Hamiltonian model of electronic structure with nonadiabatic molecular dynamics simulations, we calculate the recently measured transient photoelectron spectrum of I 2 Ϫ dissociated inside a cluster of argon atoms. We find good agreement between calculated and experimental spectra. The transient spectral shifts reflect the dynamics of(More)
The interaction potentials between the six lowest electronic states of 1, and an arbitrary discrete charge distribution are calculated approximately using a one-electron model. The model potentials are much easier to calculate than ab initio potentials, with the cost of a single energy point scaling linearly with the number of solvent molecules, enabling(More)