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Numerous behavioral studies have suggested that normal aging negatively affects source memory accuracy for various kinds of associations. Neuroimaging evidence suggests that less efficient retrieval processing (temporally delayed and attenuated) may contribute to these impairments. Previous aging studies have not compared source memory accuracy and(More)
Improving the ability to detect Alzheimer's disease (AD) at the earliest stages is essential to effectively treat afflicted individuals. Electrophysiological signatures are a promising avenue for earlier diagnosis. In the present study, we investigated an ERP component associated with visual working memory capacity, the contralateral delay activity (CDA).(More)
Memory loss resulting from damage to the medial temporal lobes (MTL) is traditionally considered to reflect damage to a dedicated, exclusive memory system. Recent work, however, has suggested that damage to one MTL structure, the perirhinal cortex (PRC), compromises complex object representations that are necessary for both memory and perception. These(More)
UNLABELLED Rodent models of anxiety have implicated the ventral hippocampus in approach-avoidance conflict processing. Few studies have, however, examined whether the human hippocampus plays a similar role. We developed a novel decision-making paradigm to examine neural activity when participants made approach/avoidance decisions under conditions of high or(More)
Many behavioral studies have shown that memory is enhanced for emotionally salient events across the lifespan. It has been suggested that this mnemonic boost may be observed for both age groups, particularly the old, in part because emotional information is retrieved with less effort than neutral information. Neuroimaging evidence suggests that inefficient(More)
The aim was to describe variation in length of the dorsal hoof wall in contact with the dermis for cows on a single farm, and hence, derive minimum appropriate claw lengths for routine foot trimming. The hind feet of 68 Holstein-Friesian dairy cows were collected post mortem, and the internal structures were visualised using x-ray µCT. The internal distance(More)
Behavioral evidence from the young suggests spatial cues that orient attention toward task-relevant items in visual working memory (VWM) enhance memory capacity. Whether older adults can also use retrospective cues ("retro-cues") to enhance VWM capacity is unknown. In the current event-related potential (ERP) study, young and old adults performed a VWM task(More)
Visual short-term memory (VSTM) is a vital cognitive ability, connecting visual input with conscious awareness. VSTM performance declines with mild cognitive impairment (MCI) and medial temporal lobe (MTL) amnesia. Many studies have shown that providing a spatial retrospective cue ("retrocue") improves VSTM capacity estimates for healthy young adults.(More)
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