Rachel McRee

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Alcoholic liver disease (ALD) is a major complication of heavy alcohol (EtOH) drinking and is characterized by three progressive stages of pathology: steatosis, steatohepatitis, and fibrosis/cirrhosis. Alcoholic steatosis (AS) is the initial stage of ALD and consists of fat accumulation in the liver accompanied by minimal liver injury. AS is known to render(More)
To test if changing magnetic fields and radiofrequency fields used in nuclear magnetic resonance imagers could induce electrical currents capable of causing localized tissue heating in metal surgical clips and prostheses, steel surgical clips, copper wire clips, and hip prostheses were exposed to fields greater than those used in the nuclear magnetic(More)
Nuclear magnetic resonance (NMR) images of live rats with sterile and pyogenic abscesses, hematomas, and various implanted and spontaneous neoplasms demonstrated good contrast differentiation between pathologic and surrounding normal tissues. This differentiation was maximal when both the T1 and T2 tissue relaxation times were used as criteria. Neoplasms(More)
A nuclear magnetic resonance (NMR) imager with a 6.5-cm aperture is described. Spatial resolution is 0.47 X 2.0 mm with a slice thickness of 8.4 mm. Contrast resolution is 3% for a 4-minute image. Because of the excellent spatial resolution and high contrast between soft tissues, the images provide a great deal of detail and reconstruction artifacts due to(More)
Steatosis is a frequent pathologic stage in alcoholic liver disease (ALD). Although the mechanisms for increased susceptibility of steatotic liver to injury have been postulated, the ability of these hepatocytes to proliferate and withstand injury is unknown. There are conflicting reports on the status of hepatocyte regeneration following chronic alcohol(More)
Live rats were imaged by nuclear magnetic resonance (NMR). These images demonstrated fine detail and high object contrast. Motion artifacts are not apparent in 4-minute images, and major blood vessels are demonstrated as regions of low signal intensity because of blood flow. Selective contrast enhancement is possible by varying NMR imager accumulation(More)
The effect of GABA in controlling luteinizing hormone releasing hormone (LHRH) release from isolated hypothalamic fragments containing the mediobasal hypothalamus, suprachiasmatic nucleus, and the preoptic area (MBH-SCN-POA) was tested under different hormonal conditions with an in vitro superfusion method. GABA significantly decreased LHRH release under(More)
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