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Genetic deficiency or pharmacological inhibition of cyclooxygenase‐1 or ‐2 induces mouse keratinocyte differentiation in vitro and in vivo
- J. Akunda, H. Lao, Christopher A. Lee, Alisha R Sessoms, Rachel M. Slade, R. Langenbach
- Biology, MedicineFASEB journal : official publication of the…
- 1 January 2004
A major effect of COX inhibitors and COX‐deficiency is the induction of keratinocyte differentiation.
Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries
Resin-bound triphenylphosphine was coupled to 4-fluoro-3-nitrobenzyl bromide, and 2-alkylthiobenzimidazoles were synthesized on Resin in 4 steps using standard chemistries, resulting in the synthesis of an 80-member test library of high purity as determined by HPLC.
A cobaloxime-mediated synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A
Cross coupling of alkyl cobaloximes with maleic anhydrides. Basic studies and applications to the synthesis of chaetomellic acid A anhydride and C-glycosyl maleic anhydrides
Abstract: Photochemical cross coupling of alkyl cobaloximes with maleic anhydrides and PhSSPh led to addition of an alkyl moiety and an SPh moiety across the alkene. Oxidation of the sulfide to a…
A cobaloxime-mediated radical route to butenolides
OXIDATIVE ADDITION OF PY(DMGH)2CO-NA+ TO A RIBOFURANOSYL BROMIDE : AN UNUSUAL REACTION WITH THE COBALOXIME LIGAND
Reaction of 2,3,5-tri-O-benzoyl-β-d-ribofuranosyl bromide (12) with NaCo(dmgH)2py (dmgH = dimethylglyoxime monoanion) in CH3CN was expected to proceed by normal oxidative addition to the…