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Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
- A. Maynard, R. Crosby, +28 authors J. Shotwell
- Chemistry, Medicine
- Journal of medicinal chemistry
- 13 March 2014
A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical polymorphic and resistant HCV mutant replicons.… Expand
Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.
- Rachel M Schmidt, Micaela M Carter, Michelle L Chu, Casey J. Latario, Sarah K Stadler, Devin L. Stauff
- Biology, Medicine
- FEMS microbiology letters
- 1 May 2016
Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive… Expand
Development of a Passive and Slope Adaptable Prosthetic Foot
We develop a passive, hydraulically operated prosthetic ankle with the capability of adapting to varying terrain in every step. Expand