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Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical polymorphic and resistant HCV mutant replicons.Expand
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Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.
Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positiveExpand
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Development of a Passive and Slope Adaptable Prosthetic Foot
We develop a passive, hydraulically operated prosthetic ankle with the capability of adapting to varying terrain in every step. Expand
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