Rachel L. West

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PURPOSE This study was conducted to determine agreement between hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging in the preoperative assessment of perianal fistulas and to compare these results with the surgical findings. METHODS Twenty-one patients (aged 26-71 years) with clinical symptoms of a(More)
OBJECTIVES The aim of this study was to determine sphincter volume, length, and external anal sphincter thickness in healthy controls and fecal incontinent patients by use of a three-dimensional reconstruction of endoanal ultrasonography images. METHODS Forty-four controls (15 males, 15 females, and 14 parous females) and 28 incontinent parous females(More)
BACKGROUND Ciprofloxacin is effective in perianal Crohn's disease but after treatment discontinuation symptoms reoccur. Infliximab is effective but requires maintenance therapy. AIM To evaluate the effect of combined ciprofloxacin and infliximab in perianal Crohn's disease. METHODS A double-blind placebo-controlled study was conducted. Patients were(More)
OBJECTIVES To determine agreement between hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography (3D HPUS) and endoanal magnetic resonance imaging (MRI) in preoperative assessment of perianal fistulas, and to assess patient preference with regard to these techniques. METHODS Forty patients (31 males, aged 21-70 years) with symptoms of a(More)
BACKGROUND Adalimumab is an effective treatment in patients with Crohn's disease; as it is a humanized anti-tumour necrosis factor monoclonal antibody, immunogenicity is thought not to be of any significance. AIM To assess whether antibodies to adalimumab (ATAs) affect adalimumab treatment outcome in patients with Crohn's disease previously treated with(More)
BACKGROUND Adalimumab is effective for the induction and maintenance of remission in Crohn's disease (CD)-patients. AIM To find predictors for adalimumab dose escalation at initiation of adalimumab. METHODS Crohn's disease patients in a single tertiary referral centre who started adalimumab between July 2007 and March 2010 at an induction dose (week 0(More)
Anal sphincter atrophy is associated with a poor clinical outcome of sphincter repair in patients with faecal incontinence. Preoperative assessment of the sphincters is therefore relevant. External anal sphincter (EAS) atrophy can be detected by endoanal magnetic resonance imaging (MRI), but not by conventional endoanal ultrasonography (EUS).(More)
OBJECTIVE It is estimated that 10%-30% of Crohn's disease (CD) patients have small-bowel lesions, but the exact frequency and clinical relevance of these findings are unknown. Double-balloon enteroscopy (DBE) enables endoscopic visualization of the small bowel. The aim of this study was to evaluate the use of DBE for detecting small-bowel lesions in CD(More)
BACKGROUND AND AIMS Genetic diversity in Castilleja grisea, an endangered, perennial herb endemic to San Clemente Island, California was investigated. Subsequent to the elimination of goats from the island in 1992, many populations of C. grisea have reappeared and have been increasing in size. METHODS Nineteen populations were surveyed for their genotype(More)
OBJECTIVE We aimed to evaluate the long term therapeutic outcome in achalasia patients treated with pneumatic dilation, specifically focusing on those patients treated more than 15 yr ago. METHODS All patients treated in our center whose records were available for review were asked to fill out a questionnaire assessing their degree of dysphagia,(More)