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Using principles derived from electric field measurements and studies of phrenic nerve in vitro, neuromagnetic stimuli in humans were predicted to excite selective low threshold sites in proximal and distal cauda equina. Physical models, in which induced electric fields were recorded in a segment of human lumbosacral spine immersed in a saline filled tank,(More)
The precise lineage relationship between innate lymphoid cells (ILC) and lymphoid tissue inducer (LTi) cells is poorly understood. Using single-cell multiplex transcriptional analysis of 100 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common proximal precursor to these lineages and showed that its bifurcation(More)
Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had(More)
Detectors for counting low energy (less than 1 MeV) ionizing events in liquid helium are developed and characterized. These devices employ wavelength shifting fluors to convert extreme ultraviolet (EUV) helium scintillation light to the visible, allowing transport of signal light to room temperature. Three technological approaches are developed and tested:(More)
The search for particle electric dipole moments ͑EDM's͒ is one of the best places to look for physics beyond the standard model of electroweak interaction because the size of time reversal violation predicted by the standard model is incompatible with present ideas concerning the creation of the baryon-antibaryon asymmetry. As the sensitivity of these EDM(More)
Innate lymphoid cells are present at mucosal sites and represent the first immune barrier against infections, but what contributes to their circulation and homing is still unclear. Using Rag2(-/-) Cxcr6(Gfp/+) reporter mice, we assessed the expression and role of CXCR6 in the circulation of ILC precursors and their progeny. We identify CXCR6 expressing ILC(More)
The Mexican axolotl V(H) segments associated with the Igh C mu and C nu isotypes were isolated from anchored PCR libraries prepared from spleen cell cDNA. The eight new V(H) segments found bring the number of V(H) families in the axolotl to 11. Each V(H) had the canonical structural features of vertebrate V(H) segments, including residues important for the(More)
The possible existence of a nonzero electric dipole moment (EDM) of the neutron is of great fundamental interest in itself and directly impacts our understanding of the nature of electro-weak and strong interactions. The experimental search for this moment has the potential to reveal new sources of T and CP violation and to challenge calculations that(More)
Inflammation triggers the differentiation of Ly6Chi monocytes into microbicidal macrophages or monocyte-derived dendritic cells (moDCs). Yet, it is unclear whether environmental inflammatory cues control the polarization of monocytes toward each of these fates or whether specialized monocyte progenitor subsets exist before inflammation. Here, we have shown(More)