Rachel E. Ashley

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The seeds of Nigella sativa (often referred to as black seed) have long been utilized as a medicinal herb in Middle Eastern, Northern African, and Indian cultures. Historically, black seed has been used to treat a variety of illnesses associated with inflammation. More recent studies have found that it induces apoptosis and displays anticancer activity in(More)
Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the catalytic cycle. Because the activities of these domains are tightly linked, it has been difficult to discern their individual contributions to enzyme-DNA interactions and drug mechanism. To further address(More)
To understand the mechanism of carcinogenesis of human malignant mesothelioma, the role of oncogenes and growth factors, which are involved in the development of the tumor should be clarified. In this study we investigated immunocytochemical expression of oncoproteins including p53, PAN-RAS, c-myc, c-jun, c-erb-B2 and WT-1, as well as growth factor(More)
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