Learn More
We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made(More)
To determine the intracellular source and release kinetics of myosin light chain 1 immediately following irreversible myocytic injury, we perfused rat hearts in a Langendorff apparatus under control conditions (20 minutes), or during global cellular injury produced by oxygenated, calcium-free perfusion (5 minutes), followed by reperfusion with buffer(More)
The progressive improvement in ability to walk without dyspnea suggested that a physiologic response similar to a training program in athletes may have been produced.' T his comment by Alvan Barach in 1951 emphasizes the-relative ignorance that existed only three decades ago concerning the " reconditioning " of patients with chronic obstructive lung disease(More)
Changes in the mean pulmonary wedge pressure were measured during temporary disconnection from a ventilator in 29 patients to assess the effects of therapy with controlled-volume ventilation on determinations of pulmonary wedge pressure. In 16 observations performed during therapy with intermittent positive-pressure ventilation, the mean value for the(More)
Minimal change nephropathy (MCN) accounts for around 25% of adults presenting with a nephrotic syndrome. Although most patients respond to corticosteroid therapy, a significant number relapse frequently and may present a real therapeutic difficulty. We present a case of apparently refractory relapsing MCN that was successfully treated with a combination of(More)
Granulomatosis with Polyangiitis (GPA) is a necrotising granulomatous vasculitis. We describe a case of GPA with cerebral involvement and review the literature. A 59-year-old man presented with symptoms of intermittent nasal obstruction and reduced hearing. He had a history of type II diabetes mellitus, managed with oral hypoglycaemic agents with no(More)
  • 1