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This paper has been compiled from a presentation given by the first author to the "Palliative and End of Life Care in Chronic Kidney Disease: The Evidence" meeting held in London in October 2006. It summarizes some of what is known about the topic as well as the authors' research and experience in the field.
BACKGROUND AND OBJECTIVES There is ongoing growth of elderly populations with ESRD in Western Europe and North America. In our center, we offer an alternative care pathway of 'maximum conservative management' (MCM) to patients who elect not to start dialysis, often because of a heavy burden of comorbid illness and advanced age. The objective of our study(More)
Mitochondrial membrane potentials (MMP) reflect the functional status of mitochondria within cells. Fluorescent probes to estimate these potentials within cells have been available for some time, but measurements of populations of mitochondria are not possible by existing methods. Therefore, comparisons between different cell types (e.g., fibroblasts and(More)
The fruition of a life of engagement and reflection, James Gustave Speth's latest book, The Bridge at the Edge of the World, is a passionate and incisive call for the environmental movement to deepen its critique and enlarge its politics. A leading environmentalist since the 1960s, Speth's perspective has evolved with the changing times, his worldview(More)
Arabidopsis thaliana is the model species of current plant genomic research with a genome size of 125 Mb and approximately 28,000 genes. The function of half of these genes is currently unknown. The purpose of this study is to infer gene function in Arabidopsis using machine-learning algorithms applied to large-scale gene expression data sets, with the goal(More)
To investigate mechanisms of inhibition of hypoxic pulmonary vasoconstriction (HPV), we studied pulmonary artery smooth muscle cell (PASMC) responses to hypoxia, utilizing diphenyleneiodonium (DPI), which blocks HPV. We measured cell contraction in primary cultures of rat PASMC grown on collagen gels and cytosolic free Ca2+ concentration ([Ca2+]i) in PASMC(More)