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1. Associative memory function was analyzed in a realistic biophysical simulation of rat piriform (olfactory) cortex containing 240 pyramidal cells and 58 each of two types of inhibitory interneurons. Pyramidal cell simulations incorporated six different intrinsic currents and three different synaptic currents. We investigated the hypothesis that(More)
Six cases are described in which hysterical seizures developed after incest and disappeared after psychotherapeutic exploration of the incestuous experience. Patients were adolescents referred for seizures, suicide attempts, sexual problems, and running away. It is suggested that Navajo and Galenic folk beliefs connecting epilepsy with incest may derive(More)
OBJECTIVE To compare rates of severe relapse and total direct and indirect costs over a 2-year period between US-based employees with multiple sclerosis (MS) who were adherent and non-adherent to disease-modifying drugs (DMDs). METHODS Employees with ≥1 MS diagnosis (ICD-9-CM: 340.x) and ≥1 DMD pharmacy claim between 1/1/2002-12/31/2007 were identified(More)
BACKGROUND Health care costs increase in patients with more severe asthma, but the effect of asthma exacerbations on costs among patients with more severe asthma has not been quantified. OBJECTIVE This study compared direct health care costs between patients with moderate/severe persistent asthma with and without exacerbations. METHODS Patients who had(More)
BACKGROUND Adolescents with newly diagnosed depression may not receive timely antidepressant therapy. Clinical and economic effects of early versus late treatment initiation are unclear. OBJECTIVE To compare effects of early versus late initiation of second-generation (SSRI/SNRI) antidepressants on emergency room (ER) visits, hospitalizations and(More)
INTRODUCTION While previous studies have noted that hypogonadism (HG) may pose a significant economic and quality-of-life burden, no studies have evaluated the impact of HG on healthcare utilization and costs in the United States. AIM Compare direct (health care) and indirect (disability leave or medical absence) costs between privately insured U.S.(More)
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