Rachel B. Clipp

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With few exceptions, previous models of the pulmonary vascular system have neglected the effects of respiration. This practice is acceptable for normal cardiac function; however, for compromised function, respiration may be critical. Therefore, we have initiated the steps to develop boundary conditions that incorporate the effects of respiration through the(More)
When modeling the cardiovascular system, the use of boundary conditions that closely represent the interaction between the region of interest and the surrounding vessels and organs will result in more accurate predictions. An often overlooked feature of outlet boundary conditions is the dynamics associated with regulation of the distribution of pressure and(More)
Pharmacokinetics/pharmacodynamics models were designed and integrated into the BioGears® physiology engine to address the need for real time drug effects for varying patients and injury profiles. Ten drugs were validated using experimental and subject matter expert data. The plasma concentration curves had a good fit with experimental data and 48 of 50(More)
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