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The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome
Drosophila melanogaster now has the most extensive genomic deletion coverage and breakpoint subdivision as well as the most comprehensive inventory of haploinsufficient genes of any multicellular organism.
Genetic basis for a rare floral mutant in an Andean species of Solanaceae.
Comparison of anthocyanin gene sequences revealed a putative loss-of-function mutation, an 11 amino-acid deletion in dihydroflavonol 4-reductase (DFR), in the white morph, indicating that the structural mutation at Dfr underlies the rare white flower morph of I. calycinum.
HDAC1 Is a Required Cofactor of CBFβ-SMMHC and a Potential Therapeutic Target in Inversion 16 Acute Myeloid Leukemia
It is demonstrated that in vivo treatment with the HDAC1 inhibitor entinostat decreased leukemic burden, and induced differentiation and apoptosis of leukemia cells, and that inhibitors ofHDAC1 effectively target leukemia cells expressing the fusion protein in vivo.