Rachana Parmar

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Resistance problems with caspofungin, an echinocandin inhibitor of fungal cell wall glucan synthesis, have been rare. We noted paradoxical turbid growth of Candida albicans isolates in broth in some high (supra-MIC) concentrations. Among isolates submitted for susceptibility testing and screened at drug concentrations up to 12.5 microg/ml, the frequency was(More)
We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine(More)
Studies were done to develop a murine model that mimics the pattern of mucosal candidiasis followed by disseminated disease seen in patients given cytotoxic chemotherapy. Developmental studies showed that suppression of mice with 5-fluorouracil beginning 3 days prior to infection and given every 7 days thereafter necessitated antibacterial treatment but(More)
Paradoxical growth of some Candida albicans isolates in the presence of caspofungin (CAS) in vitro has been demonstrated previously. We sought to determine whether a similar phenomenon occurred in vivo. A systemic model of candidiasis was studied in CD-1 mice by intravenous inoculation of different isolates of C. albicans. Infected animals were treated with(More)
Central nervous system (CNS) aspergillosis is a severe disease that responds poorly to current therapies. The current studies examined the efficacies of several antifungal agents alone or in combination with a murine model of CNS aspergillosis. Immunosuppressed mice were infected intracerebrally with Aspergillus fumigatus and treated with an amphotericin B(More)
BACKGROUND CNS aspergillosis is the most frequent and devastating manifestation of dissemination and mortality is high. METHODS Cyclophosphamide-suppressed CD-1 mice were infected intracerebrally with conidia of Aspergillus fumigatus and treated for 10 days with suboptimal doses of Abelcet (4 mg/kg) plus micafungin (1 mg/kg), caspofungin (1 mg/kg),(More)
This paper proposes a novel framework for mining regional co-location patterns with respect to sets of continuous variables in spatial datasets. The goal is to identify regions in which multiple continuous variables with values from the wings of their statistical distribution are co-located. A co-location mining framework is introduced that operates in the(More)
This paper presents a novel region discovery framework geared towards finding scientifically interesting places in spatial datasets. We view region discovery as a clustering problem in which an externally given fitness function has to be maximized. The framework adapts four representative clustering algorithms, exemplifying prototype-based, gridbased,(More)
Feature-based hot spots are localized regions where the attributes of objects attain high values. There is considerable interest in automatic identification of feature-based hot spots. This paper approaches the problem of finding feature-based hot spots from a data mining perspective, and describes a method that relies on supervised clustering to produce a(More)
This paper proposes a novel framework for mining regional colocation patterns with respect to sets of continuous variables in spatial datasets. The goal is to identify regions in which multiple continuous variables with values from the wings of their statistical distribution are co-located. A co-location mining framework is introduced that operates in the(More)