Rachael F. Schultz

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BACKGROUND The targeting of the immune system through immunotherapies to prevent tumor tolerance and immune suppression are at the front lines of breast cancer treatment and research. Human and laboratory studies have attributed breast cancer progression and metastasis to secondary organs such as the bone, to a number of factors, including elevated levels(More)
Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, myeloproliferation, extramedullary hematopoiesis, splenomegaly and leukemic progression. Moreover, the bone marrow and spleens of individuals with PMF contain large numbers of atypical megakaryocytes that are postulated to contribute to fibrosis through the release of cytokines, including(More)
The majority of patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) harbor mutations in JAK2 or MPL, which lead to constitutive activation of the JAK/STAT, PI3K and ERK signaling pathways. JAK inhibitors by themselves are inadequate in producing selective clonal suppression in MPN and are associated with hematopoietic toxicities. MK-2206 is a(More)
Laser Raman spectroscopy has been used to examine the conformations of the protein and phospholipid components of sarcoplasmic reticulum from rabbit white skeletal muscle. The phospholipid component is shown to have the conformation of fluid, liquid-crystalline lipids, even at 10 degrees C, and no breaks in the lipid conformation are observed in the range(More)
The interaction of lysozyme with mixed 1,2-dipalmitoyl-L-phosphatidic acid/1,2-dimyristoyl-L-phosphatidylcholine liposomes was investigated by laser Raman spectroscopy. Substantial changes were observed i the spectra of both the lipid and protein in the mixed liposomes over the range 10-62 degrees C. At temperatures below 27 degrees C, interaction with(More)
L-leucine-beta-naphthylamide (LNA) will support growth of a leucine auxotroph of Salmonella typhimurium. Utilization of this compound depends on the presence in the cells of active peptidase N. Selection for improved growth on a suboptimal concentration of LNA yields mutants some of which contain elevated levels of peptidase N. The properties of these(More)
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