Rabeay Y A Hassan

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The severity of infections caused by Candida albicans, the most common opportunistic human fungal pathogen, needs rapid and effective antifungal treatments. One of the effective ways is to control the virulence factors of the pathogen. Therefore, the current study examined the effects of genistein, a natural isoflavone present in soybeans, on C. albicans.(More)
AIMS Metabolic pathways, e.g. biosynthesis of ergosterol or carbohydrate metabolism including respiration, are well-known targets of several fungicides. With our study we wanted to prove that metabolite profiles can be used to classify fungicides according to their mode of action and that concentrations of key metabolites are changed even without detectable(More)
Most antibiotics were discovered via their inhibition of growth of target organisms. However, yeasts in particular have the capability to adapt metabolic pathways to the availability of nutrients e.g. yeasts can easily switch between respiratory and fermentative pathways in response to oxygen concentration, or can even use both simultaneously. Thus, we(More)
Candida albicans is an opportunistic fungal pathogen with comparably high respiratory activity. Thus, we established a viability test based on 2,6-dichlorophenolindophenol (DCIP), a membrane-permeable electron transfer agent. NADH dehydrogenases catalyze the reduction of DCIP by NADH, and the enzymatic activity can be determined either electrochemically via(More)
Microbial infections are rapidly increasing; however most of the existing microbiological and molecular detection methods are time consuming and/or cannot differentiate between the viable and dead cells which may overestimate the risk of infections. Therefore, a bioelectrochemical sensing platform with a high potential to the microbial-electrode(More)
Due to the potential interest, bioelectrochemical responses of activated sludge using the three-electrode system are tested. From the cyclic voltammograms, the oxidation current output is increasing due to incubation time increase, whereas 5, 25 and 39.33 μA are obtained after 3, 72 and 96 h, respectively. Changing the working electrode from glassy carbon(More)
The present study reports, for the first time, the development and use of core-shell amino-terminated chitosan (Cs) hyperbranched nanoparticles (HBCs-NH2 NPs) as a novel natural polymer-based electrode modifier for efficient electrochemical systems. The electrochemical activity of the developed HBCs-NH2 NPs as compared to Cs NPs was identified by standard(More)
Despite advances made in the field, rapid detection methods for the human pathogen Candida albicans are still missing. In this regard, bio-electrochemical systems including electrochemical sensors and biosensors satisfy the increasing demand for rapid, reliable, and direct microbial analyses. In this study, the bioelectrochemical characteristics of C.(More)
In the microbial electrochemical system (MES), the microbial-electrode interactions are often regulated by the metabolic pathway and respiratory activities. To improve the efficiency of MES, there is a need to introduce a microbial community that provides a continuous oxidation of organic substrates with a sustainable current output. Thus, activated sludge(More)
Staphylococcus aureus is one of the most dangerous human pathogens and is the cause of numerous illnesses ranging from moderate skin infections to life-threatening diseases. Despite advances made in identifying microorganisms, rapid detection methods for the viability of bacteria are still missing. Here, we report a rapid electrochemical assay for cell(More)
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