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The mechanisms underlying many important properties of the human atrial action potential (AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents based on data recorded from human atrial myocytes, along with representations of pump, exchange, and background currents, we developed a mathematical model of the AP. The model AP(More)
Dogs have been used extensively to study atrial arrhythmias, but there are no published mathematical models of the canine atrial action potential (AP). To obtain insights into the ionic mechanisms governing canine atrial AP properties, we incorporated formulations of K(+), Na(+), Ca(2+), and Cl(-) currents, based on measurements in canine atrial myocytes,(More)
UNLABELLED Recent advances in molecular electrophysiology have made possible the development of more selective ion channel blockers for therapeutic use. However, more information is needed about the effects of blocking specific channels on repolarization in normal human atrium and in atrial cells of patients with atrial fibrillation (AF). AF-induced(More)
The performance deterioration caused by updates to databases or data structures can be overcome by reorganizing the structure from time to time. In previous work, optimal reorganization intervals were determined for linearly increasing deterioration costs and linearly growing reorganization cost. To date only heuristics have been available for non-linear(More)
The primary objectives of this thesis are to develop and implement a quantitative method for predicting shoreline changes within reasonable temporal and spatial limits, and to better understand the processes controlling shoreline movement. A mathematical model for the prediction of future shorelines is developed for integration of the relevant(More)
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