Raúl García

César Nombela4
José Manuel Rodríguez-Peña2
Clara Bermejo2
4César Nombela
2José Manuel Rodríguez-Peña
2Clara Bermejo
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In Saccharomyces cerevisiae, the transcriptional program triggered by cell wall stress is coordinated by Slt2/Mpk1, the mitogen-activated protein kinase (MAPK) of the cell wall integrity (CWI) pathway, and is mostly mediated by the transcription factor Rlm1. Here we show that the SWI/SNF chromatin-remodeling complex plays a critical role in orchestrating(More)
—The Florida Public Hurricane Loss Model (FPHLM) is a large scale, multidisciplinary project developed to assist the state of Florida with the regulation of residential insurance premiums as they relate to insured losses caused by hurricane winds. The modeling services provided to clients using the FPHLM involve physically distributed personnel with(More)
Within the field of Saccharomyces cerevisiae functional genomics, DNA microarrays have become a very useful tool to study genome-wide gene-expression changes under diverse experimental conditions. Here, the design and production of a gene microarray, called the 'yeast cell wall chip', specifically tailored to investigate cell wall functions, is described.(More)
The transcriptional response of Saccharomyces cerevisiae to cell wall stress is mainly mediated by the cell wall integrity (CWI) pathway through the MAPK Slt2 and the transcription factor Rlm1. Once activated, Rlm1 interacts with the chromatin remodeling SWI/SNF complex which locally alters nucleosome positioning at the target promoters. Here we show that(More)
Inferior vena cava (IVC) leiomyosarcoma is a rare malignant neoplasm more commonly seen in women in the fifth to sixth decade of life. Complete resection of the tumor with negative margins is the only therapeutical option that has demonstrated a survival benefit. This report presents a case of a 67-year-old woman affected by a lower segment IVC(More)
  • Raúl García, Javier Botet, José Manuel Rodríguez-Peña, Clara Bermejo, Juan Carlos Ribas, José Luis Revuelta +2 others
  • 2015
The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised. Functional genomic approaches provide a unique opportunity to globally characterize these adaptive mechanisms. To provide(More)
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