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The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. Interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Many studies have(More)
Within the past few years, the focus on cytokine single nucleotide polymorphism (SNP) function and association with human diseases has increased considerably. This third supplement to the Cytokine Gene Polymorphism in Human Disease: On-line database describes the positive associations of cytokine SNPs in human diseases described in articles published from(More)
The recent recognition that FcyRIII (CD16) expressed on polymorphonuclear leu-kocytes (FcyRIIIPMN)t is a glycosyl-phosphatidylinositol (GPI) anchored molecule (1-3) has heightened interest in the functional roles of human Fcy receptors (FcyR). The potential for rapid lateral mobility within the membrane (4, 5) and the lack ofan obvious mechanism to couple(More)
Clearance of immune complexes by the mononuclear phagocyte system is important for maintaining normal host defenses against bacterial and viral assault (1), but also contributes to the pathogenesis of a variety of immune-mediated diseases. For example, removal from the circulation of IgG-coated erythrocytes and platelets by the MPS is the sine qua non of(More)