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Clearance of immune complexes by the mononuclear phagocyte system is important for maintaining normal host defenses against bacterial and viral assault (1), but also contributes to the pathogenesis of a variety of immune-mediated diseases. For example, removal from the circulation of IgG-coated erythrocytes and platelets by the MPS is the sine qua non of(More)
The recent recognition that FcyRIII (CD16) expressed on polymorphonuclear leu-kocytes (FcyRIIIPMN)t is a glycosyl-phosphatidylinositol (GPI) anchored molecule (1-3) has heightened interest in the functional roles of human Fcy receptors (FcyR). The potential for rapid lateral mobility within the membrane (4, 5) and the lack ofan obvious mechanism to couple(More)
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