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A series of new piperid-4-ylethane derivatives possessing antiarrhythmic activity has been synthesized and studied. The most active compound, 1-(4-fluorophenyl)-1-(4-nitrobenzoylamino)-2-(N-ethylpiperid-4-yl)ethane (niferidyl) hydrochloride, was selected for clinical trials as a potential class III antiarrhythmic drug.
AIM To study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus A (IVA) in cell culture. MATERIAL AND METHODS The activity of the drugs against viral(More)
The effect of the antiviral drug arbidol on the reproduction of avian influenza A/H5 viruses was studied in in vitro experiments. The strains were isolated from the wild birds of Eastern Siberia and they were closely related to the 1997-2000 viruses from South-Eastern Asia. Arbidol was shown to exert a selective inhibiting effect on the reproduction of(More)
The value of the chemical shift was calculated by an additive method: C7H(C6H) = 6Ho + Zortho, where 6Ho is the chemical shift of the C6H or CTH proton in the unsubstituted pyrrolopyrimidine, and Zorth o is the change in 6Ho following introduction of the substituent X into the five--membered ring. The increments Zorth o were obtained from the benzene(More)
Microiontophoretic application of melatonin to the perineuronal space of nerve cells in the lateral hypothalamus of WAG and Fischer-344 rats led to decreases in the frequency and regularization of the spike activity of neurons, and also blocked activation of neurons and changing the patterns of adrenaline-induced spike activity. The effects of melatonin(More)
The immunomodulating activity of arbidole was studied in cultured cells, animals, and human beings. Arbidole was shown to have effects on nonspecific defense factors, on its capacity to induce interferon and activate phagocytes in particular. Arbidole-treated patients with lower baseline immunity showed improvement in immunological parameters (in the counts(More)
The first data on the molecular mechanism of the antiviral action of I are presented for the first time in this work. As is well known, the mechanism of the reproduction of influenza virus is unique, since it provides for specific cooperation of viral and cell factors. Therefore, to determine the mechanism of the antiviral action of I we studied its(More)
This study was aimed at modification of the structures of pyrazinamide and isoniazid by substituting amidine and hydrazidine instead of amide and hydrazide moieties. The target compounds are of independent basic interest and can be used as prodrugs. In the first stage, pyrazinocarboxylic (I) and isonicotinic (V) acid amides were converted into the(More)
Alzheimer’ disease (AD) is a progressive neurodegenerative cerebral disorder mostly incident in presenile and senile age, which was originally described by the German neurologist A. Alzheimer (1864 – 1915). In recent years, there has been an increase in AD incidence statistics in some countries, which explains the greater attention paid to the study of this(More)