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Anterior fontanel pressure (AFP), a noninvasive indicator of intracranial pressure (ICP), was monitored during tracheal intubation in two groups of preterm neonates without neurologic disease. Anterior fontanel pressure was monitored and recorded continuously with a Ladd AFP monitor. Systolic and mean blood pressures were recorded at 1-min intervals. In(More)
Predicting immediate neonatal morbidity after perinatal asphyxia has been difficult. A review of asphyxiated neonates greater than or equal to 36 weeks' gestation admitted to The Children's Hospital Newborn Intensive Care Unit in 1983 was conducted to devise a scoring system that would rapidly predict organ dysfunction observed in the immediate neonatal(More)
Due to the high mortality associated with pulmonary interstitial emphysema in the low-birth-weight infant, a method was developed to predict the infants most at risk for death. This information will allow the discriminant selection of patients for future trials of an alternative method of mechanical ventilation, high-frequency ventilation. During a(More)
The effects of a number of dopamine-receptor agonists on depolarization-induced (26 mM K+) release of 3H-acetylcholine from slices of rat caudate nucleus were examined with a superfusion method. Apomorphine (10−6 M) and N,N-dipropyliso-ADTN (10−7 M) inhibited acetylcholine-release in vitro by about 50% and these inhibitory effects were antagonized by(More)
The effects of anesthetics on intracranial pressure (ICP) may be different in preterm neonates than in adults because the neonate's cranial sutures are not yet fused. The authors monitored changes in anterior fontanel pressure (AFP), a noninvasive indicator of ICP, during anesthesia in 44 preterm neonates without neurologic disease. Atropine, 0.02 mg/kg,(More)
Three main symptoms of minimal brain dysfunction (MBD), a common disorder in children, are hyperactivity, learning disabilities, and attention deficits. Drugs like amphetamine and methylphenidate have been demonstrated to produce a significant behavioral improvement in these children. The behavioral response of young rats (3–4 weeks), with selective(More)
In our hospital pharmacy an injectable solution of haloperidol decanoate 141 mg/ml (equivalent to haloperidol 100 mg/ml) in sesame oil was prepared. The aim of this study was to prove bioequivalence of this formulation with the reference product, Haldol Decanoas®. 15 schizophrenic patients, already stabilized with Haldol Decanoas®, were enrolled.(More)
An LLC-PK1 cell culture model was used to evaluate for a direct protective effect of the pentoxifylline analogue HWA-448 in gentamicin nephrotoxicity at the cellular level. Cells exposed to 2 mM gentamicin for 6 days displayed a significant decrease in specific activities of leucine aminopeptidase, NaK ATPase, and N-acetyl glucosaminidase, and an increase(More)
We describe a biopsy-confirmed case of acute interstitial nephritis associated with the use of loracarbef in an 18-month-old boy, which resulted in end-stage renal failure. This complication has been documented with the use of beta-lactam antibiotics, and it seems likely the loracarbef was responsible for acute interstitial nephritis in this patient.