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A deleterious gene achieves a population balance between the opposing forces of selection and mutation. In this paper we explore the nature of this stochastic balance when the surrounding normal population is not at equilibrium. Assuming that new mutations occur according to a Poisson process and thereafter evolve by the rules of a continuous time branching(More)
Haplotype mapping has emerged in the past few years as a powerful tool for the fine mapping of disease genes. It is typically carried out on a sample of affected individuals from a population isolate. If the chromosome neighborhood of a disease gene is saturated with markers, then each new mutation in the population or existing mutation introduced by a(More)
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