The Catharanthus alkaloids: pharmacognosy and biotechnology.
- R. van der Heijden, D. I. Jacobs, W. Snoeijer, D. Hallard, R. Verpoorte
- Chemistry, BiologyCurrent Medicinal Chemistry
- 29 February 2004
Despite the availability of only a limited number of biosynthetic genes, the research on C. roseus has already led to a broad scientific spin-off and it is clear that many interesting results can be expected when more genes become available.
Molecular Cloning and Analysis of Strictosidine β-d-Glucosidase, an Enzyme in Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus *
- A. Geerlings, Matias Martinez-Lozano Ibañez, J. Memelink, R. van der Heijden, R. Verpoorte
- Biology, ChemistryJournal of Biological Chemistry
- 4 February 2000
Results show that coordinate induction of the biosynthetic genes forms at least part of the mechanism for the methyl jasmonate-induced increase in TIA production, and new insight in SGD localization has significant implications for the understanding of the complex intracellular trafficking of metabolic intermediates during TIA biosynthesis.
Geraniol 10‐hydroxylase1, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis
- Graziella Collu, N. Unver, A. Peltenburg-Looman, R. van der Heijden, R. Verpoorte, J. Memelink
- Chemistry, BiologyFEBS Letters
- 16 November 2001
Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
- C. Canel, M. I. Lopes-Cardoso, R. Verpoorte
- BiologyPlanta
- 1 July 1998
It is concluded that constitutive over-expression of Str is highly desirable for increased TIA production, however, given its complexity, limited intervention in the TIA pathway will yield positive results only in the presence of a favorable epigenetic environment.
The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture
- A. Contin, R. van der Heijden, A. Lefeber, R. Verpoorte
- ChemistryFEBS Letters
- 4 September 1998
Biosynthesis of anthraquinones in cell cultures of the Rubiaceae
- Ying Han, R. van der Heijden, R. Verpoorte
- Biology, ChemistryPlant Cell Tissue and Organ Culture
- 1 December 2001
Findings demonstrate that the 2-C-methyl-D-erythritol 4-phosphate pathway, not the mevalonic acid pathway, is involved in the formation of isopentenyl diphosphate, which constitutes ring C of anthraquinones in the Rubiaceae.
RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model.
- Chunxiu Hu, Judith van Dommelen, T. Hankemeier
- Biology, ChemistryJournal of Proteome Research
- 8 October 2008
A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric method was developed for the profiling of lipids in human and mouse plasma and was successfully applied to p53 mutant mice plasma for studying some phenotypic effects of p53 expression.
Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function.
- A. Ramos-Valdivia, R. van der Heijden, R. Verpoorte
- BiologyNatural product reports (Print)
- 1997
Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology
- Mei Wang, R. Lamers, J. van der Greef
- Chemistry, BiologyPhytotherapy Research
- 1 March 2005
The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products and to advance the development of scientific based herbal medicine.
Analytical strategies in lipidomics and applications in disease biomarker discovery.
- Chunxiu Hu, R. van der Heijden, Mei Wang, J. van der Greef, T. Hankemeier, Guowang Xu
- Biology, ChemistryJournal of chromatography. B, Analytical…
- 15 September 2009
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