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Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Background— Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection.… Expand
A human monoclonal antibody blocking SARS-CoV-2 infection
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this… Expand
Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique.
The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined variations in shear stress in a straight vessel… Expand
Large variations in absolute wall shear stress levels within one species and between species.
Wall shear stress (WSS), the frictional force between blood and endothelium, is an important determinant of vascular function. It is generally assumed that WSS remains constant at a reference value… Expand
The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region.
Cytoplasmic linker proteins (CLIPs) have been proposed to mediate the interaction between specific membranous organelles and microtubules. We have recently characterized a novel member of this… Expand
Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice.
- R. van Haperen, A. van Tol, +7 authors R. de Crom
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 April 2000
Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoprotein particles and alters high density lipoprotein (HDL) subfraction patterns in vitro, but its physiological… Expand
Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines.
We previously found that low shear stress (LSS) induces atherosclerotic plaques in mice with increased lipid and matrix metalloproteinase content and decreased vascular smooth muscle and collagen… Expand
The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization.
- H. Dubbink, L. de Waal, R. van Haperen, N. Verkaik, J. Trapman, J. Romijn
- Biology, Medicine
- 1 August 1998
Human prostate-specific transglutaminase (hTGP) is a cross-linking enzyme secreted by the prostate. In this study, we performed dot blot analysis of 50 normal human tissues to demonstrate… Expand
Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice.
Phospholipid transfer protein (PLTP) is a multifunctional protein synthesized by various cell types and secreted into the plasma. Plasma PLTP is able to transfer phospholipids between lipoproteins… Expand
Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice
- S. P. Jones, James J. M. Greer, R. van Haperen, D. Duncker, R. de Crom, D. Lefer
- Proceedings of the National Academy of Sciences…
- 3 April 2003
Congestive heart failure results in cardiovascular dysfunction and diminished vascular nitric oxide (NO) production. We hypothesized that overexpression of endothelial NO synthase (eNOS) within the… Expand