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HIV-1 persistence in CD4+ T cells with stem cell-like properties
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harborExpand
A model predictive control based scheduling method for HIV therapy.
We have developed a model predictive control (MPC) based method for determining optimal treatment interruption schedules that are robust to errors due to measurement and patient variations. Expand
The Tobit Kalman Filter: An Estimator for Censored Measurements
We present a novel formulation of the Kalman filter for Tobit Type 1 censored measurements, which we call the Tobit Kalman Filter. Expand
Long-Term Antiretroviral Treatment Initiated at Primary HIV-1 Infection Affects the Size, Composition, and Decay Kinetics of the Reservoir of HIV-1-Infected CD4 T Cells
ABSTRACT Initiation of antiretroviral therapy during the earliest stages of HIV-1 infection may limit the seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviralExpand
Enhancing immune response to HIV infection using MPC-based treatment scheduling
Using recently developed models of the interaction of the human immune system and the Human Immunodeficiency Virus (HIV), we have developed a model predictive control (MPC) based method for determining optimal treatment interruption schedules. Expand
HIV Model Parameter Estimates from Interruption Trial Data including Drug Efficacy and Reservoir Dynamics
Mathematical models based on ordinary differential equations (ODE) have had significant impact on understanding HIV disease dynamics and optimizing patient treatment. A model that characterizes theExpand
Nonlinear estimators for censored data: A comparison of the EKF, the UKF and the Tobit Kalman filter
The Tobit Kalman filter is a new method that is a computationally efficient, unbiased estimator for linear dynamical systems with censored output. Expand
Model-driven approaches for in vitro combination therapy using ONYX-015 replicating oncolytic adenovirus.
Replicating genetically modified adenoviruses have shown promise as a new treatment approach against cancer. Recombinant adenoviruses replicate only in cancer cells which contain certain mutations,Expand
Estimation of saturated data using the Tobit Kalman filter
Saturated data arises naturally in a number of engineering applications. Expand
Modeling Uncertainty in Single-Copy Assays for HIV
ABSTRACT We present a simple computational model of measurement accuracy for single-copy sensitivity assays (SCA) of HIV RNA that was developed from first principles. The model shows that the SCA isExpand