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- Publications
- Influence
A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood.
- A. Pfefferbaum, D. Mathalon, E. Sullivan, J. Rawles, R. Zipursky, K. Lim
- Medicine
- Archives of neurology
- 1 September 1994
OBJECTIVE
To model in vivo the dynamic interrelations of head size, gray matter, white matter, and cerebrospinal fluid (CSF) volumes from infancy to old age using magnetic resonance imaging (MRI).
… Expand
Antipsychotic drug effects on brain morphology in first-episode psychosis.
- J. Lieberman, G. Tollefson, +11 authors M. Tohen
- Medicine, Psychology
- Archives of general psychiatry
- 1 April 2005
BACKGROUND
Pathomorphologic brain changes occurring as early as first-episode schizophrenia have been extensively described. Longitudinal studies have demonstrated that these changes may be… Expand
Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia.
- S. Kapur, R. Zipursky, C. Jones, G. Remington, S. Houle
- Psychology, Medicine
- The American journal of psychiatry
- 1 April 2000
OBJECTIVE
Since all antipsychotics block dopamine D(2) receptors, the authors investigated how well D(2) receptor occupancy in vivo predicts clinical response, extrapyramidal side effects, and… Expand
Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia.
- S. Kapur, R. Zipursky, G. Remington
- Medicine
- The American journal of psychiatry
- 1 February 1999
OBJECTIVE
Dopamine D2 receptor occupancy measurements provide a valid predictor of antipsychotic response, extrapyramidal side effects, and elevation of prolactin levels. The new antipsychotics… Expand
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
- T. McGlashan, R. Zipursky, +12 authors A. Breier
- Psychology, Medicine
- The American journal of psychiatry
- 1 May 2006
OBJECTIVE
This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia.
METHOD
This… Expand
A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.
- S. Kapur, R. Zipursky, C. Jones, C. Shammi, G. Remington, P. Seeman
- Psychology, Medicine
- Archives of general psychiatry
- 1 June 2000
BACKGROUND
Quetiapine is a new atypical antipsychotic medication. As such, relatively little has been published regarding its in vivo effects at the dopamine type 2 (D2) and serotonin type 2a… Expand
Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol.
- J. Lieberman, G. Tollefson, +9 authors R. Hamer
- Psychology, Medicine
- The American journal of psychiatry
- 1 August 2003
OBJECTIVE
Few long-term studies have compared the efficacy and safety of typical and atypical antipsychotic medications directly in patients with a first episode of psychosis who met the criteria for… Expand
Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation.
- Z. Daskalakis, B. Christensen, R. Chen, P. Fitzgerald, R. Zipursky, S. Kapur
- Psychology, Medicine
- Archives of general psychiatry
- 1 April 2002
BACKGROUND
Cortical inhibition (CI) deficits have been proposed as a pathophysiologic mechanism in schizophrenia. This study employed 3 transcranial magnetic stimulation (TMS) paradigms to assess CI… Expand
A systematic review of longitudinal outcome studies of first-episode psychosis.
- N. Menezes, T. Arenovich, R. Zipursky
- Psychology, Medicine
- Psychological medicine
- 1 October 2006
BACKGROUND
Existing outcome literature has had an over-representation of chronic patients and suggested a progressive course and poor outcome for schizophrenia. The current study aimed to recombine… Expand
Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study.
- Kate McKenna, G. Koren, +6 authors A. Einarson
- Medicine
- The Journal of clinical psychiatry
- 15 April 2005
BACKGROUND
A substantial number of women of childbearing age suffer from schizophrenia and other mental illnesses that require the use of antipsychotic drugs. Atypical antipsychotics have been on the… Expand