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A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood.
TLDR
These patterns of growth and change seen in vivo with MRI are largely consistent with neuropathological studies, as well as animal models of development, and may reflect neuronal progressive and regressive processes, including cell growth, myelination, cell death, and atrophy.
Antipsychotic drug effects on brain morphology in first-episode psychosis.
TLDR
Patients with first-episode psychosis exhibited a significant between-treatment difference in MRI volume changes, and post hoc analyses suggested that treatment effects on brain volume and psychopathology of schizophrenia may be associated.
Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia.
TLDR
Clozapine, at doses known to be effective in routine clinical settings, showed a D 2 occupancy clearly lower than that of typical antipsychotics, while risperidone and olanzapine at their usual clinical doses gave the same level of D2 occupancy as low-dose typical antippsychotics.
Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia.
TLDR
The study confirms that D(2) occupancy is an important mediator of response and side effects in antipsychotic treatment, and is consistent with a "target and trigger" hypothesis of antipsychotics action.
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
TLDR
The nearly significant differences suggest that olanzapine might reduce the conversion rate and delay onset of psychosis, and was efficacious for positive prodromal symptoms but induced weight gain.
Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation.
TLDR
It is suggested that schizophrenia is associated with deficits in CI and that antipsychotic medications may increase CI.
A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.
TLDR
The data suggest that transient D2 occupancy may be sufficient for its antipsychotic effect, and future studies controlling for nonpharmacological effects as well as activities on other receptors will be necessary to confirm this suggestion.
A systematic review of longitudinal outcome studies of first-episode psychosis
TLDR
Outcome from FEP may be more favorable than previously reported, and treatment and methodological variables may be important contributors to outcome, and a multi-dimensional, globally used definition of outcome is required.
Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study.
TLDR
Results suggest that atypical antipsychotics do not appear to be associated with an increased risk for major malformations, and there were no statistically significant differences in any of the pregnancy outcomes of interest.
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