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Naturally Occurring Disulfide-bound Dimers of Three-fingered Toxins
Disulfide-bound dimers of three-fingered toxins have been discovered in the Naja kaouthia cobra venom; that is, the homodimer of α-cobratoxin (a long-chain α-neurotoxin) and heterodimers formed byExpand
Isolation, characterization and molecular cloning of Duplex-Specific Nuclease from the hepatopancreas of the Kamchatka crab
BackgroundNucleases, which are key components of biologically diverse processes such as DNA replication, repair and recombination, antiviral defense, apoptosis and digestion, have revolutionized theExpand
Analysis of proteins interacting with TRIP8b adapter
Calcium-independent receptor of latrotoxin (CIRL) is an orphan heptahelical receptor implicated in regulation of exocytosis. To characterize molecular mechanisms of CIRL functioning, we searched forExpand
Induction of resistance to murine tumor development is associated with alterations in the glycosylation of blood serum proteins.
The phenomenon of accelerated metastatic tumor growth following the removal of the primary tumor is a major reason for cancer relapse, caused by underlying mechanisms that are not as yet understood.Expand
Characteristics of Sarcoplasmic Reticulum Membrane Preparations Isolated from Skeletal Muscles of Active and Hibernating Ground Squirrel Spermophilus undulatus
The total Ca-ATPase activity in the sarcoplasmic reticulum (SR) membrane fraction isolated from skeletal muscles of winter hibernating ground squirrel Spermophilus undulatus is ∼2.2-fold lower thanExpand
cDNA cloning, structural, and functional analyses of venom phospholipases A₂ and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi.
Snake venom phospholipases A₂ (PLA₂s) display a wide array of biological activities and are each characteristic to the venom. Here, we report on the cDNA cloning and characterization of PLA₂s fromExpand
[Biologically active peptides isolated from the brain of hibernating ground squirrels].
More than 20 peptides have been isolated and sequenced from the brain of hibernating ground squirrel Citellus undulatus. Some of the isolated peptides were chemically synthesized and investigated forExpand
Solid phase isotope exchange of deuterium and tritium for hydrogen in human recombinant insulin
Reaction of a high-temperature solid-phase catalytic isotope exchange in peptides and proteins under the action of the catalytically activated spillover hydrogen was studied. The reaction of humanExpand
New paradoxical three-finger toxin from the cobra Naja kaouthia venom: Isolation and characterization
A new three-finger toxin nakoroxin was isolated from the cobra Naja kaouthia venom, and its complete amino acid sequence was established. Nakoroxin belongs to the group of “orphan” toxins, data onExpand
Neuropeptide Modulation of Evoked Responses of Neurons in the Medial Septal Region of Hibernating Ground Squirrels in Conditions of Chronic Isolation of the Medial Septal Region from
Septal slices from hibernating ground squirrels were initially (for two weeks) subjected to basal separation of the septal region and were then used for studies of the effects of neuropeptidesExpand
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