A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
- D. Hunter, P. Kraft, S. Chanock
- Biology, MedicineNature Genetics
- 27 May 2007
Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies.
Migration patterns and breast cancer risk in Asian-American women.
- R. Ziegler, R. Hoover, M. Hyer
- MedicineJournal of the National Cancer Institute
- 17 November 1993
Exposure to Western lifestyles had a substantial impact on breast cancer risk in Asian migrants to the United States during their lifetime, and this study should provide new insights into the etiology of breast cancer.
The landscape of recombination in African Americans
- A. Hinch, Arti Tandon, S. Myers
- BiologyNature
- 20 July 2011
This work builds a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans, and identifies about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans.
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
A three-stage genome-wide association study of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1.
The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust
- D. Silverman, C. Samanic, M. Attfield
- MedicineJournal of the National Cancer Institute
- 6 June 2012
The findings provide further evidence that diesel exhaust exposure may cause lung cancer in humans and may represent a potential public health burden and an interaction between smoking and 15-year lagged cumulative REC was attenuated in the presence of high levels of the other.
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
- Shahana Ahmed, G. Thomas, D. Easton
- Biology, MedicineNature Genetics
- 1 May 2009
Strong evidence is found for additional susceptibility loci on 3p and 17q and potential causative genes include SLC4A7 and NEK10 on3p and COX11 on 17q.
Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
- R. Stolzenberg-Solomon, Shih-chen Chang, R. Ziegler
- MedicineAmerican Journal of Clinical Nutrition
- 1 April 2006
The results do not support the hypothesis that high folate intake reduces breast cancer risk but suggest that a high intake, generally attributable to supplemental folic acid, may increase the risk in postmenopausal women, and confirm previous studies showing positive associations between moderate alcohol consumption and breast cancer.
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
- M. García-Closas, F. Couch, P. Kraft
- Biology, MedicineNature Genetics
- 1 April 2013
SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.
Tofu and risk of breast cancer in Asian-Americans.
- A. Wu, R. Ziegler, M. Pike
- MedicineCancer Epidemiology, Biomarkers and Prevention
- 1 November 1996
Risk of breast cancer decreased with increasing frequency of intake of tofu after adjustment for age, study area, ethnicity, and migration history; the adjusted OR associated with each additional serving per week was 0.85 (95% CI = 0.74-0.99).
Dietary diversity and subsequent mortality in the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study.
- A. Kant, A. Schatzkin, T. Harris, R. Ziegler, G. Block
- MedicineAmerican Journal of Clinical Nutrition
- 1 March 1993
D diets that omitted several food groups were associated with an increased risk of mortality, and the inverse diversity-mortality association was adjusted for potential confounders.
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