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F1012‐2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy
TLDR
It is reported that F1012‐2, a novel SL active fraction, isolated from Eupatorium lindleyanum DC.
Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells.
TLDR
The results revealed that arctigenin significantly inhibited the migration and invasion of MDA-MB-231 cells by downregulating M MP-2, MMP-9 and heparanase expression.
A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Potential Antitumor Effective Substances and Mechanism of Phellinus igniarius
TLDR
This study provides knowledge on the chemical composition and antitumor mechanism of P. igniarius, which may be exploited as a promising therapeutic option for colon cancer.
Tetrahydroxystilbene Glucoside Exerts Cytoprotective Effect against Hydrogen Peroxide-induced Cell Death Involving ROS Production and Antioxidant Enzyme Activation
TLDR
It is demonstrated that tetrahydroxystilbene glucoside exerted stronger cytoprotective effect against peroxide-induced cell death in gastric epithelial cells than gastric cancer cells and the cy toprotective mechanisms might be through decreasing oxidative stress and activating the expression of hemeoxygenase-1 and NADPH quinone oxidoreductase- 1.