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Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormalExpand
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BLM helicase facilitates Mus81 endonuclease activity in human cells.
Bloom syndrome is a rare, autosomal recessive inherited disorder in humans. The product of the Bloom syndrome mutated gene, designated BLM, is a member of the RecQ helicase family. BLM has beenExpand
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The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode.
Trehalose synthase (TreS) catalyzes the reversible conversion of maltose into trehalose in mycobacteria as one of three biosynthetic pathways to this nonreducing disaccharide. Given the importance ofExpand
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Functional Glycosylation Sites of the Rat Luteinizing Hormone Receptor Required for Ligand Binding (*)
The contribution of N-linked glycosylation to the ligand binding activity of the rat luteinizing hormone receptor (LHR) was studied in wild-type and mutant LHR expressed in mammalian (COS1) cells andExpand
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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase
The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombinationExpand
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Comprehensive characterization of the site-specific N-glycosylation of wild-type and recombinant human lactoferrin expressed in the milk of transgenic cloned cattle.
The glycosylation profile of a recombinant protein is important because glycan moieties can play a significant role in the biological properties of the glycoprotein. Here we determined theExpand
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The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53* 210
BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN, unwind Holliday junctions (HJ), an activity that could suppressExpand
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Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function. In contrast to mice carrying two distinct POT1 genes encoding two POT1Expand
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The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation.
The S-glycosyltransferase SunS is a recently discovered enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of proteins. This study reports the discovery of aExpand
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Isolation and characterization of two novel rat ovarian lactogen receptor cDNA species.
Two novel lactogen receptor cDNA clones (2.1 and 1.2 kb) were isolated from a rat ovarian cDNA library. Nucleotide sequence of the 2.1 kb clone codes for a 610 aa receptor (nonglycosylated mol. wgt.Expand
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