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T cell receptor signalling networks: branched, diversified and bounded
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation. Acquisition of appropriate effector T cell function requires the participation of multiple signals fromExpand
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T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance
Summary:  T‐cell development in the thymus and activation of mature T cells in secondary lymphoid organs requires the ability of cells to respond appropriately to environmental signals at multipleExpand
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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
Vav is a GTP/GDP exchange factor (GEF) for members of the Rho-family of GTPases that is rapidly tyrosine-phosphorylated after engagement of the T cell receptor (TCR), suggesting that it may transduceExpand
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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
Immunological memory depends on the long-term maintenance of memory T cells. Although the factors that maintain CD8 T cell memory are well understood, those responsible for CD4 memory are not wellExpand
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A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes.
The T cell repertoire is shaped by positive and negative selection of thymocytes that express low levels of T cell receptor (TCR) and both CD4 and CD8. TCR-mediated signals that determine theseExpand
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Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function
Loss of the phosphatase PTPN22 enhances the functions of both effector and regulatory T cells. Tipping Both Sides of the Inflammatory Scales Autoimmune disorders arise because of an imbalance in theExpand
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How Many Thymocytes Audition for Selection?
T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major histocompatibility complex (MHC) ligands to initiate positive and negativeExpand
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Sensory Adaptation in Naive Peripheral CD4 T Cells
T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs.Expand
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The influence of the src‐family kinases, Lck and Fyn, on T cell differentiation, survival and activation
The src‐family kinases p56lck (Lck) and p59fyn (Fyn) are expressed in T cells and are among the first signaling molecules to be activated downstream of the T cell receptor (TCR). Evidence is emergingExpand
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TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells1
The role of TCR signals triggered by recognition of self MHCs in maintaining the survival of naive peripheral T cells remains controversial. Here we examine the role of the Src family kinases, p56lckExpand
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