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Tapentadol - A representative of a new class of MOR-NRI analgesics.
Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food andExpand
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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically, CIPN is a mostlyExpand
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[Reccomendation of Polish Respiratory Society for palliative care in chronic lung diseases].
1. Ewa Jassem, Klinika Alergologii, Gdański Uniwersytet Medyczny — przewodnicząca 2. Halina Batura-Gabryel, Katedra i Klinika Pulmonologii, Alergologii i Onkologii Pulmonologicznej, UniwersytetExpand
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Diagnosis and management of neuropathic pain: review of literature and recommendations of the Polish Association for the Study of Pain and the Polish Neurological Society - Part Two.
Neuropathic pain may be caused by a variety of lesions or diseases of both the peripheral and central nervous system. The most common and best known syndromes of peripheral neuropathic pain areExpand
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Transdermal and Topical Drug Administration in the Treatment of Pain
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age,Expand
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Diagnosis and management of neuropathic pain: review of literature and recommendations of the Polish Association for the study of pain and the Polish Neurological Society - part one.
Neuropathic pain still present a major diagnostic and therapeutic challenge despite considerable progress in understanding of its mechanisms and publication of number of studies which assessed theExpand
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Peripheral opioid analgesia in laparoscopic cholecystectomy
Background Recent research has revealed that opioids can act directly on the peripheral terminals of afferent nerves to mediate antinociception. The aim of this study was to assess the influence ofExpand
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Perioperative Immunosuppression and Risk of Cancer Progression: The Impact of Opioids on Pain Management
Opioids comprise an important group of drugs used in cancer pain pharmacotherapy. In recent years, more and more studies have emerged indicating the potentially immunosuppressive effects of opioidExpand
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The role of oxycodone/naloxone in the management of patients with pain and opioid-induced constipation
ABSTRACT Introduction: Common opioid adverse effects (AE) of the gastrointestinal tract include opioid-induced constipation (OIC) and opioid-induced bowel dysfunction (OIBD) with traditionalExpand
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Pathophysiology and clinical characteristics of pain in most common locations in cancer patients.
Pain is one of the most common symptoms in cancer patients, especially in advanced disease. However, pain also accompanies a significant percentage of patients during diagnostic and therapeuticExpand
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