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Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
- G. Ascoli, L. Alonso-Nanclares, +36 authors R. Yuste
- Psychology, Medicine
- Nature Reviews Neuroscience
- 1 July 2008
A representative group of researchers are convened to agree on a set of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex, and the resulting terminology might provide a stepping stone towards a future classification of these complex and heterogeneous cells. Expand
Attractor dynamics of network UP states in the neocortex
It is concluded that network UP states are circuit attractors—emergent features of feedback neural networks that could implement memory states or solutions to computational problems. Expand
Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data
- E. Pnevmatikakis, Daniel Soudry, +13 authors L. Paninski
- Medicine, Computer Science
- 20 January 2016
This work presents a modular approach for analyzing calcium imaging recordings of large neuronal ensembles that relies on a constrained nonnegative matrix factorization that expresses the spatiotemporal fluorescence activity as the product of a spatial matrix that encodes the spatial footprint of each neurons in the optical field and a temporal matrix that characterizes the calcium concentration of each neuron over time. Expand
Morphological changes in dendritic spines associated with long-term synaptic plasticity.
There is no evidence that changes in the morphology of spines after LTP are necessary or sufficient for the induction or maintenance of LTP, but a strong correlation between synaptic plasticity and morphological changes in spines is shown. Expand
Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity
This work finds precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro, which repeat after minutes, maintaining millisecond accuracy. Expand
Genesis of dendritic spines: insights from ultrastructural and imaging studies
The developmental generation of dendritic spines is reviewed, covering recent live imaging experiments and older ultrastructural data, and the potential role of dendedritic filopodia in spine development and recent findings of spinogenesis in adult animals are addressed. Expand
Dendritic spines as basic functional units of neuronal integration
It is concluded that calcium channels exist in spine heads; action potentials invade the spines; spines are individual calcium compartments; and spines can individually detect the temporal coincidence of pre- and postsynaptic activity, and thus serve as basic functional units of neuronal integration. Expand
Fast nonnegative deconvolution for spike train inference from population calcium imaging.
- J. Vogelstein, A. Packer, +4 authors L. Paninski
- Computer Science, Biology
- Journal of neurophysiology
- 9 December 2009
This work presents a fast nonnegative deconvolution filter to infer the approximately most likely spike train of each neuron, given the fluorescence observations, which outperforms optimal linear deconVolution (Wiener filtering) on both simulated and biological data. Expand
Dense Inhibitory Connectivity in Neocortex
This work maps the inhibitory connectivity between upper layers somatostatin-positive GABAergic interneurons and pyramidal cells in mouse frontal cortex and concludes that local inhibitory connections are promiscuous, does not form subnetworks, and can approach the theoretical limit of a completely connected synaptic matrix. Expand
Dense, Unspecific Connectivity of Neocortical Parvalbumin-Positive Interneurons: A Canonical Microcircuit for Inhibition?
It is concluded that the microcircuit architecture for PV+ interneurons, and probably neocortical inhibition in general, is an unspecific, densely homogenous matrix covering all nearby pyramidal cells. Expand