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Genesis of dendritic spines: insights from ultrastructural and imaging studies
Dendritic spines are small protrusions from many types of neuron, which receive most of the excitatory inputs to the cell. Spines are thought to have important roles in neural information processingExpand
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Fast nonnegative deconvolution for spike train inference from population calcium imaging.
Fluorescent calcium indicators are becoming increasingly popular as a means for observing the spiking activity of large neuronal populations. Unfortunately, extracting the spike train of each neuronExpand
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Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho.
Dendritic spines mediate most excitatory transmission in the mammalian CNS and have been traditionally considered stable structures. Following the suggestion that spines may 'twitch', it has beenExpand
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Dense Inhibitory Connectivity in Neocortex
The connectivity diagram of neocortical circuits is still unknown, and there are conflicting data as to whether cortical neurons are wired specifically or not. To investigate the basic structure ofExpand
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Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies
Dendritic spines are critical elements of cortical circuits, since they establish most excitatory synapses. Recent studies have reported correlations between morphological and functional parametersExpand
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Modular Propagation of Epileptiform Activity: Evidence for an Inhibitory Veto in Neocortex
What regulates the spread of activity through cortical circuits? We present here data indicating a pivotal role for a vetoing inhibition restraining modules of pyramidal neurons. We combined fastExpand
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Dense, Unspecific Connectivity of Neocortical Parvalbumin-Positive Interneurons: A Canonical Microcircuit for Inhibition?
GABAergic interneurons play a major role in the function of the mammalian neocortex, but their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate uncaging to opticallyExpand
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Dynamics of Spontaneous Activity in Neocortical Slices
The flow of activity in the cortical microcircuitry is poorly understood. We use calcium imaging to reconstruct, with millisecond and single-cell resolution, the spontaneous activity of populationsExpand
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Developmental regulation of spine motility in the mammalian central nervous system.
The function of dendritic spines, postsynaptic sites of excitatory input in the mammalian central nervous system (CNS), is still not well understood. Although changes in spine morphology may mediateExpand
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New insights into the classification and nomenclature of cortical GABAergic interneurons
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergicExpand
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