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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
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Transcriptional regulatory code of a eukaryotic genome
TLDR
An initial map of yeast's transcriptional regulatory code is constructed by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species.
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Transcriptional Regulatory Networks in Saccharomyces cerevisiae
TLDR
This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
TLDR
The epigenetic landscape of enhancer elements in embryonic stem cells and several adult tissues in the mouse is interrogated and it is found that histone H3K27ac distinguishes active enhancers from inactive/poised enhancers and poised enhancer networks provide clues to unrealized developmental programs.
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Super-Enhancers in the Control of Cell Identity and Disease
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
TLDR
It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
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Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
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Remodeling of yeast genome expression in response to environmental changes.
TLDR
The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change and extend the understanding of the role of activators in effecting this response.
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