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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gain… Expand
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
- T. I. Lee, Nicola J. Rinaldi, +18 authors R. Young
- Biology, Medicine
- Science
- 25 October 2002
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as maps of metabolic… Expand
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- W. A. Whyte, David A. Orlando, +6 authors R. Young
- Biology, Medicine
- Cell
- 1 April 2013
Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report… Expand
Histone H3K27ac separates active from poised enhancers and predicts developmental state
- M. Creyghton, A. Cheng, +10 authors R. Jaenisch
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 24 November 2010
Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These… Expand
Super-Enhancers in the Control of Cell Identity and Disease
- Denes Hnisz, B. Abraham, +5 authors R. Young
- Biology, Medicine
- Cell
- 1 November 2013
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology… Expand
Polycomb complexes repress developmental regulators in murine embryonic stem cells
- L. Boyer, K. Plath, +13 authors R. Jaenisch
- Biology, Medicine
- Nature
- 18 May 2006
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability to differentiate into virtually all adult cell types are not well understood. Polycomb group (PcG) proteins… Expand
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2)… Expand
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- J. Lovén, Heather A. Hoke, +6 authors R. Young
- Chemistry, Medicine
- Cell
- 1 April 2013
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, we… Expand
Remodeling of yeast genome expression in response to environmental changes.
- H. Causton, B. Ren, +7 authors R. Young
- Biology, Medicine
- Molecular biology of the cell
- 1 February 2001
We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes in… Expand
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES… Expand
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