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Behavioral and biochemical investigations of bupropion metabolites.
- M. Bondarev, Tatiana S Bondareva, R. Young, R. Glennon
- Chemistry, MedicineEuropean journal of pharmacology
- 1 August 2003
S,S-Hydroxybupropion possessed affinity at the dopamine transporter comparable to bupropion, and was also found to bind at the norepinephrine transporter, and probably play a role in the complex actions of this agent.
Drug‐induced discrimination: A description of the paradigm and a review of its specific application to the study of hallucinogenic agents
Nicotine and bupropion share a similar discriminative stimulus effect.
The results demonstrated that bupropion can produce a nicotine-like response in nicotine-trained animals, but it does so via a mechanism of action that is unlike that of nicotine.
Comparison of the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) and cocaine: asymmetric generalization.
- N. Khorana, M. Pullagurla, R. Young, R. Glennon
- Psychology, MedicineDrug and alcohol dependence
- 11 June 2004
The results indicate that stimulus substitution between MDMA and cocaine is asymmetric and suggest that although similarities exist between the stimulus actions of ecstasy and cocaine, differences might be explained by their differential effects on increasing synaptic concentrations of serotonin, dopamine, and/or norepinephrine.
Further investigation of the discriminative stimulus properties of MDA
Rats trained to discriminate racemic MDA from saline can apparently recognize members of both classes of agents, suggesting that the stimulus effects of S(+)-MDA are predominantly amphetamine-like while those of R(-)-Mda are more DOM-like.
In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
- R. Rothman, Nga Vu, +6 authors R. Glennon
- Chemistry, MedicineJournal of Pharmacology and Experimental…
- 1 October 2003
The data indicate that the pharmacological effects of ephedrine-like phenylpropanolamines are likely mediated by norepinephrine release, and although sharing mechanistic similarities with, they differ in important respects from those of the phenyl Propanonamines methcathinone and cathin one and the phenyisopropylamines methamphetamine and amphetamine.
Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists.
The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).
Further studies on N-methyl-1(3, 4-methylenedioxyphenyl)-2-aminopropane as a discriminative stimulus: Antagonism by 5-hydroxytryptamine3 antagonists
- R. Glennon, R. Higgs, R. Young, H. Issa
- Medicine, PsychologyPharmacology Biochemistry and Behavior
- 1 December 1992
It is concluded that MDMA produces its stimulus effects via a complex mechanism involving both dopaminergic and serotonergic components.
Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies
In-depth analyses of the nature and use of drugs as discriminative stimuli are provided and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology.
Discriminative stimulus properties of amphetamine and structurally related phenalkylamines