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Interaction between midazolam and clarithromycin: comparison with azithromycin.
It is concluded that a drug interaction exists between midazolam and clarithromycin which could be of clinical importance and no such effect is present with azithromyc. Expand
Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam.
Pharmacodynamic tests consistently showed significant differences after erythromycin pretreatment compared to control, but not after azithromycin, which causes clinically significant changes in the pharmacokinetics and pharmacodynamics of midazolam. Expand
The reaction between organic nitrates and sulfhydryl compounds. A possible model system for the activation of organic nitrates.
It is suggested that, in vivo, a thionitrate could function as an important intermediate in the activation of guanylate cyclase. Expand
Fluconazole: comparison of pharmacokinetics, therapy and in vitro susceptibility
The susceptibility of fungi to fluconazole in vitro and in vivo correlates well with the concentrations of the drug measured in various compartments of the body, which means that the dosage may need to be decreased in patients with renal impairment. Expand
Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin.
It was concluded that coadministration of midazolam and azithromycin involves less clinical risk than with the 2 macrolides. Expand
Administration of the antimycotic agents fluconazole and itraconazole to leukaemia patients: a comparative pharmacokinetic study.
It is concluded that there is no clinically important pharmacokinetic interaction between fluconazole and the chemotherapeutic agents given to this group of patients and the sharp increases and decreases in AUC during the course of the trial found for some patients in the itraconazole group suggest the need for caution. Expand
Comparative pharmacokinetics of fluconazole and of itraconazole in Japanese and in German subjects.
In separate but identically designed studies the oral pharmacokinetics of 100 mg doses of the 2 antimycotics fluconazole and itraconazole were examined in Japanese and German subjects (both n = 12),Expand
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
It is concluded that the reaction between NO and soluble quanylate cyclase is a real but minor cause of tolerance to organic nitrates. Expand
Induction of conformational changes in bovine liver glutamate dehydrogenase by a steroid analogue. I
Abstract Glutamate dehydrogenase ( l -glutamate: NAD(P) + oxidoreductase (deaminating). EC catalyses the reductive amination of α-ketoglutarate. It was shown that under certain conditionsExpand
Interaction of beef-heart mitochondrial ATPase, coupling factor F1, with aurovertin.
  • R. Yeates
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 22 February 1974
Evidence is presented that in the absence of added magnesium, F1 can hydrolyse low concentrations of added ATP, and that it stems from aurovertin binding followed by a slow conformational change in F1. Expand