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Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB against… Expand
A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice.
Green tea has been shown to be a potent chemopreventive agent against lung tumorigenesis in animal models. Previously, we found that treatment of A/J mice with either green tea (0.6% in water) or a… Expand
Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine.
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumor. To explore these changes, oligonucleotide array analysis was performed on RNA obtained… Expand
A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells
The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been… Expand
Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.
- R. Lubet, R. Yao, Clinton J. Grubbs, Ming You, Yian Wang
- Chemistry, Medicine
- Chemico-biological interactions
- 10 November 2009
Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats was… Expand
Expression of S100 protein family members in the pathogenesis of bladder tumors.
- R. Yao, A. Lopez-Beltran, G. Maclennan, R. Montironi, J. Eble, L. Cheng
- Medicine, Biology
- Anticancer research
- 1 September 2007
The S100 proteins act as multifactional signaling factors that are involved in the regulation of diverse cellular processes. To explore the involvement of S100 genes in bladder cancers, S100 gene… Expand
Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
Budesonide, a glucocorticoid, was proven to be a highly effective agent in preventing the development of lung tumors in A/J mice. In a lung tumor bioassay, budesonide produced 70% inhibition of tumor… Expand
Gene expression profiling of chemically induced rat bladder tumors.
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumors. To explore expression changes in 4-hydroxybutyl(butyl)nitrosamine-induced rat bladder… Expand
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
The Ras protein undergoes a series of post-translational modifications at the C-terminal CAAX motif, which culminates with the anchoring of p21 Ras to the plasma membrane where it relays growth… Expand
Effect of an Epidermal Growth Factor Receptor Inhibitor in Mouse Models of Lung Cancer
Gefitinib (Iressa, ZD1839) is a potent high-affinity competitive tyrosine kinase inhibitor aimed primarily at epidermal growth factor receptor (EGFR). Inhibitors in this class have recently been… Expand