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Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB againstExpand
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A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice.
Green tea has been shown to be a potent chemopreventive agent against lung tumorigenesis in animal models. Previously, we found that treatment of A/J mice with either green tea (0.6% in water) or aExpand
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Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine.
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumor. To explore these changes, oligonucleotide array analysis was performed on RNA obtainedExpand
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A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells
The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has beenExpand
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Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.
Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats wasExpand
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Expression of S100 protein family members in the pathogenesis of bladder tumors.
The S100 proteins act as multifactional signaling factors that are involved in the regulation of diverse cellular processes. To explore the involvement of S100 genes in bladder cancers, S100 geneExpand
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Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
Budesonide, a glucocorticoid, was proven to be a highly effective agent in preventing the development of lung tumors in A/J mice. In a lung tumor bioassay, budesonide produced 70% inhibition of tumorExpand
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Gene expression profiling of chemically induced rat bladder tumors.
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumors. To explore expression changes in 4-hydroxybutyl(butyl)nitrosamine-induced rat bladderExpand
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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
The Ras protein undergoes a series of post-translational modifications at the C-terminal CAAX motif, which culminates with the anchoring of p21 Ras to the plasma membrane where it relays growthExpand
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Effect of an Epidermal Growth Factor Receptor Inhibitor in Mouse Models of Lung Cancer
  • Y. Yan, Yan Lu, +5 authors M. You
  • Medicine, Biology
  • Molecular Cancer Research
  • 1 December 2006
Gefitinib (Iressa, ZD1839) is a potent high-affinity competitive tyrosine kinase inhibitor aimed primarily at epidermal growth factor receptor (EGFR). Inhibitors in this class have recently beenExpand
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