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Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony- stimulating factor and interferon gamma
Activated macrophages (M phi s) are important participants in host defense, but their uncontrolled activation leads rapidly to septic shock and death. One mechanism for regulating other dangerousExpand
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Nitric oxide participates in the regulation of pancreatic acinar cell secretion.
The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in isolated rat pancreatic acini. NO synthase activity was detected in the extract of acini and purified byExpand
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Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.
A widespread occurrence of Ca2+-dependent protein kinase was shown in various tissues and phyla of the animal kingdom. Phosphatidylserine appeared to be more effective than calmodulin in supportingExpand
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Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.
At least two substrate proteins for phospholipid-sensitive Ca2+-dependent protein kinase and at least six substrates for calmodulin-sensitive Ca2+-dependent protein kinase were identified in theExpand
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Direct effect of the neurotoxicant acrylamide on kinesin‐based microtubule motility
Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be aExpand
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Phorbol ester induces intracellular translocation of phospholipid/Ca2+ ‐dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini
Treatment of intact rat pancreactic acini with phorbol ester (12‐O‐tetradecanoyl‐phorbol‐13‐acetate, TPA) resulted in a time‐ and concentration‐dependent translocation of phospholipid/Ca2+ ‐dependentExpand
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Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c‐fos and c‐myb in smooth muscle cells
Hyperhomocysteinemia has been recognized as an independent risk factor for cerebral, coronary, and peripheral atherosclerosis. To examine the contribution of homocysteine (H[cys]) in the pathogenesisExpand
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Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells
MCF-7 cells growing in culture were used to study the mechanism of the antiproliferative activity of the antiprogestin mifepristone, as compared with the antiestrogen 4-hydroxytamoxifen or theExpand
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Sarcoplasmic reticulum-associated and protein kinase C-regulated ADP-ribosyl cyclase in cardiac muscle.
Two types of ADP-ribosyl cyclase activity were distinguished in dog and rat cardiac muscles by measuring the enzymatic conversion of NGD (as an NAD analog) into the fluorescent product cyclicExpand
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Carbachol stimulates TYR phosphorylation and association of PKCdelta and PYK2 in pancreas.
  • R. Wrenn
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 13 April 2001
Carbachol treatment resulted in increased phosphorylation on tyrosine of PKCdelta immunoprecipitated from rat pancreatic acinar cells. The Ca2+-dependent tyrosine kinase PYK2 coimmunoprecipitatedExpand
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