• Publications
  • Influence
Dopamine, learning and motivation
  • R. Wise
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 1 June 2004
TLDR
Dopamine release in the nucleus accumbens has been linked to the efficacy of these unconditioned rewards, but dopamine release in a broader range of structures is implicated in the 'stamping-in' of memory that attaches motivational importance to otherwise neutral environmental stimuli. Expand
A psychomotor stimulant theory of addiction.
TLDR
A new attempt at a general theory of addiction is offered, based on the common denominator of the psychomotor stimulants---amphetamine, cocaine, and related drugs---rather than on thecommon denominators of the socalled depressant drugs~opiates, barbiturates, alcohol, and others. Expand
Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats.
TLDR
The cycles of excessive drinking and abstinence led to an increase in ethanol preference and increased efficacy of both acamprosate and naltrexone in Long-Evans rats, which promises to be a valuable tool in the alcohol research field. Expand
Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines
TLDR
Comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3H-dopamine into synaptosomes from frontal cortex, caudate nucleus, and nucleus accumbens from wild-type, NET, and dopamine transporter (DAT) knock-out mice suggests that dopamine in this region is normally cleared by the somewhat promiscuous NET. Expand
Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
TLDR
Challenging the idea that any of these inputs encode motivationally neutral information, activation of each discrete pathway reinforced instrumental behaviors, demonstrating that behavioral reinforcement is an explicit consequence of strong excitatory drive to the NAc. Expand
Neuroadaptation: Incubation of cocaine craving after withdrawal
TLDR
Behavioural evidence is provided from laboratory animals suggesting that the onset of craving is delayed and that craving does not decay, but rather increases progressively, over a two-month withdrawal period. Expand
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
TLDR
A long-lasting cocaine-induced neuroadaptation, presumably at the level of glutamate terminals in the VTA, appears to play an important role in stress-induced relapse to drug use. Expand
Brain dopamine and reward.
While the evidence is strong that dopamine plays some fundamental and special role in the rewarding effects of brain stimulation, psychomotor stimulants, opiates, and food, the exact nature of thatExpand
Addictive drugs and brain stimulation reward.
  • R. Wise
  • Psychology, Medicine
  • Annual review of neuroscience
  • 1996
TLDR
The reward-potentiating effects of amphetamine and opiates are associated with central sites of action where these drugs also have their direct rewarding effects, suggesting common mechanisms for drug reward per se and for drug potentiation of brain stimulation reward. Expand
Brain Reward Circuitry Insights from Unsensed Incentives
  • R. Wise
  • Medicine, Psychology
  • Neuron
  • 10 October 2002
TLDR
Comparisons of natural and laboratory incentives suggest hypotheses as to why some habits become compulsive and give insights into the roles of reinforcement and of prediction of reinforcement in habit formation. Expand
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