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Comparative testing of monoclonal antibodies against Plasmodium falciparum sporozoites for ELISA development.
TLDR
Two monoclonal antibodies developed against Plasmodium falciparum sporozoites at four institutions were evaluated for use in an enzyme-linked immunosorbent assay (ELISA) and one had the highest sensitivity, a requirement for lower concentrations of capture antibody, and had been tested successfully against sporozoite from a wider range of geographical areas than the others. Expand
Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.
TLDR
The R TS,S/AS01B malaria vaccine warrants comparative field trials with RTS,S /AS02A to determine the best formulation for the protection of children and infants. Expand
Evidence for transmission of Plasmodium vivax among a duffy antigen negative population in Western Kenya.
TLDR
It is shown that a parasite with characteristics of Plasmodium vivax is being transmitted among Duffy blood group-negative inhabitants of Kenya, and positives were found late in the rainy season, when An. Expand
Bloodmeal identification by direct enzyme-linked immunosorbent assay (ELISA), tested on Anopheles (Diptera: Culicidae) in Kenya.
TLDR
A direct enzyme-linked immunosorbent assay (ELISA) was developed for bloodmeal identification of seven hosts and a system was developed whereby a single mosquito could be tested by both the blood meal ELISA and the malaria sporozoite ELISA. Expand
Chagas Disease in a Domestic Transmission Cycle in Southern Texas, USA
TLDR
After three dogs died from acute Chagas cardiomyopathy at one location, an investigation was conducted of the home, garage, and grounds of the owner to predict areas where the vector Tryiatoma gerstaeckeri might be expected. Expand
Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
TLDR
Phenotypic heterogeneity in the repetitive portion of a human malaria circumsporozoite (CS) protein, a major target of candidate vaccines, has been found and implies that a P. vivax vaccine based on the CS protein repeat of one isolate will not be universally protective. Expand
Emergence of a new neotropical malaria vector facilitated by human migration and changes in land use.
TLDR
In a region of northeastern Amazonia, a species previously of minor importance, Anopheles marajoara, is found to be the principal malaria vector, and a significantly higher proportion of this species is infected with malaria parasites, determined by the ELISA technique. Expand
Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.
TLDR
The gene for the circumsporozoite (CS) protein of Plasmodium falciparum has been cloned and its nucleotide sequence determined and suggests that they may have a function such as binding to liver cells and may represent an invariant target for immunity. Expand
Biting behavior and Plasmodium infection rates of Anopheles arabiensis from Sille, Ethiopia.
TLDR
The man-biting behavior and Plasmodium infection rates of anopheline mosquitoes were investigated in Sille, a hyperendemic malarious area in southern Ethiopia and found no association between biting behavior and sporozoite infection status. Expand
Field evaluation of enzyme-linked immunosorbent assays for Plasmodium falciparum and Plasmodium vivax sporozoites in mosquitoes (Diptera: Culicidae) from Papua New Guinea.
TLDR
Enzyme-linked immunosorbent assays (ELISA's) were compared with dissection results on mosquitoes of the Anopheles punctulatus Doenitz complex collected in Papua New Guinea and eliminated the requirement for salivary-gland sporozoites as quantitative positive controls. Expand
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