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Comparative testing of monoclonal antibodies against Plasmodium falciparum sporozoites for ELISA development.
Ten monoclonal antibodies developed against Plasmodium falciparum sporozoites at four institutions were evaluated for use in an enzyme-linked immunosorbent assay (ELISA). Four of the antibodies wereExpand
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Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.
BACKGROUND To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals). METHODS In aExpand
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Evidence for transmission of Plasmodium vivax among a duffy antigen negative population in Western Kenya.
We present evidence that a parasite with characteristics of Plasmodium vivax is being transmitted among Duffy blood group-negative inhabitants of Kenya. Thirty-two of 4,901 Anopheles gambiae and An.Expand
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Bloodmeal identification by direct enzyme-linked immunosorbent assay (ELISA), tested on Anopheles (Diptera: Culicidae) in Kenya.
A direct enzyme-linked immunosorbent assay (ELISA) was developed for bloodmeal identification of seven hosts. Commercially available reagents are used; the test can be completed in only 4.5 h. BloodExpand
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Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
Phenotypic heterogeneity in the repetitive portion of a human malaria circumsporozoite (CS) protein, a major target of candidate vaccines, has been found. Over 14% of clinical cases of uncomplicatedExpand
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Emergence of a new neotropical malaria vector facilitated by human migration and changes in land use.
In a region of northeastern Amazonia, we find a species previously of minor importance, Anopheles marajoara, to be the principal malaria vector. In a total of five collections during 1996-97 in threeExpand
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Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.
The gene for the circumsporozoite (CS) protein of Plasmodium falciparum has been cloned and its nucleotide sequence determined. The gene encodes a protein of 412 amino acids as deduced from theExpand
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Biting behavior and Plasmodium infection rates of Anopheles arabiensis from Sille, Ethiopia.
The man-biting behavior and Plasmodium infection rates of anopheline mosquitoes were investigated in Sille, a hyperendemic malarious area in southern Ethiopia. Seven Anopheles species were identifiedExpand
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Field evaluation of enzyme-linked immunosorbent assays for Plasmodium falciparum and Plasmodium vivax sporozoites in mosquitoes (Diptera: Culicidae) from Papua New Guinea.
Enzyme-linked immunosorbent assays (ELISA's) were compared with dissection results on mosquitoes of the Anopheles punctulatus Doenitz complex collected in Papua New Guinea. Assays were based onExpand
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Malaria vectors in a traditional dry zone village in Sri Lanka.
Malaria transmission by anopheline mosquitoes was studied in a traditional tank-irrigation-based rice-producing village in the malaria-endemic low country dry zone of northcentral Sri Lanka duringExpand
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