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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
TLDR
Brain insulin resistance appears to be an early and common feature of AD, a phenomenon accompanied by IGF-1 resistance and closely associated with IRS-1 dysfunction potentially triggered by Aβ oligomers and yet promoting cognitive decline independent of classic AD pathology.
Enrichment Effects on Adult Cognitive Development
TLDR
The available evidence suggests that activities can postpone decline, attenuate decline, or provide prosthetic benefit in the face of normative cognitive decline, while at the same time indicating that late-life cognitive changes can result in curtailment of activities.
Participation in cognitively stimulating activities and risk of incident Alzheimer disease.
TLDR
Results suggest that frequent participation in cognitively stimulating activities is associated with reduced risk of AD.
Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.
TLDR
Dietary intake of n-3 polyunsaturated fatty acids and weekly consumption of fish may reduce the risk of incident Alzheimer disease.
Loneliness and risk of Alzheimer disease.
TLDR
Loneliness is associated with an increased risk of late-life dementia but not with its leading causes, and was robustly associated with cognitive decline and development of AD.
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.
TLDR
Diabetes mellitus may be associated with an increased risk of developing AD and may affect cognitive systems differentially, and this study evaluated the association of diabetes mellitus with risk of AD and change in different cognitive systems.
Physical Frailty Is Associated with Incident Mild Cognitive Impairment in Community‐Based Older Persons
TLDR
This study aims to test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI) and to establish a causal relationship between physical frailness and cognitive impairment.
Individual differences in rates of change in cognitive abilities of older persons.
TLDR
The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process.
Overview and findings from the religious orders study.
TLDR
This manuscript summarizes the study methods including the study design and describes the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data.
Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population.
TLDR
The Mediterranean dietary pattern as captured by the MedDiet scoring system may reduce the rate of cognitive decline with older age.
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