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Comparative subchronic studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in rats.
TLDR
Data demonstrated the comparable toxicities of 2,4-D acid, DMA, and 2-EHE and support a subchronic no-observed-effect level of 15 mg/kg/day for all three forms. Expand
Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents.
TLDR
The findings of these studies indicate low chronic toxicity of 2,4-D and the lack of oncogenic response to 2, 4-D following chronic dietary exposure in the rat and mouse and the chronic toxicity paralleled subchronic findings. Expand
Congenital stationary night blindness: an animal model.
TLDR
Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type, but no structural abnormalities were demonstrated that could explain the functional defect. Expand
Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms.
TLDR
No adverse fetal effects were noted at dose levels that did not also produce evidence of maternal toxicity or exceed renal clearance of 2,4-D indicating that the developing rat and rabbit fetus were not uniquely sensitive to 2, 4-D and its forms. Expand
Differentiation of the Cardiovascular Effects of CI‐581
TLDR
The following work, using three different dose levels of ketamine, was carried out to study cardiovascular parameters, and to gain some insight into the nature of these responses. Expand
In vivo micronucleus assays on 2,4-dichlorophenoxyacetic acid and its derivatives.
TLDR
The results of the mouse bone marrow micronucleus test are consistent with the reported lack of in vitro genetic toxicity for these materials in various in vitro genotoxicity assays as well as the absence of carcinogenic potential for 2,4-D in both mice and rats. Expand
Comparative subchronic and chronic dietary toxicity studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in the dog.
TLDR
Comparing toxicity among representative forms of 2,4-D and their generally low toxicity following subchronic and chronic dietary exposure in the dog are indicated. Expand
Malignant hyperpyrexia with anesthesia.
TLDR
Idiopathic explosive malignant hyperthermia, which occurs after anesthesia is given, is a syndrome of increasing prevalence and the only reasonable explanation of the etiology appears to be an uncoupling of oxidative phosphorylation. Expand
Involvement of the Sympathetic Nervous System in the Pressor Response to Ketamine
TLDR
It is demonstrated that ketamine had a direct doserelated depressive effect on the heart in vitro and that these stitnulatory effects of ketmine appear only with smaller doses and that higher doses produce a depression of the cardiovascular system. Expand
The Effect of Beta‐Adrenergic Blockade on the Cardiopulmonary Response to Ketamine
TLDR
It was concluded that the residual pressor response produced by the anesthetic agent after muscarinic blockade must be mediated via the sympathetic nervous system. Expand
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