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Pilot‐controlled trial of the extracorporeal liver assist device in acute liver failure
Assessment of additive function for the device revealed an improvement in galactose elimination capacity after 6 hours of haemoperfusion, and better indices of prognosis will be required, in addition to those used to select for transplantation, if patients at an earlier stage of clinical deterioration are to be included in future studies.
Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure
Investigation of the ultrastructural appearance of brain capillaries by scanning electron microscopy found mainly cytotoxic mechanisms, with cellular swelling, and to a lesser extent vasogenic mechanism, with altered blood‐brain barrier permeability, appear to be involved in the cerebral edema of fulminant hepatic failure.
Acute liver failure secondary to hepatic infiltration: a single centre experience of 18 cases
In every case of ALF with prodromal symptoms or abnormal imaging, hepatic histology should be obtained by liver biopsy as soon as possible to diagnose infiltrative hepatic disease.
Classification, etiology, and considerations of outcome in acute liver failure.
  • R. Williams
  • Medicine
    Seminars in liver disease
  • 1 November 1996
A variety of different hematologic, biochemical, and clinical features can be used as predictive indices of the likely outcome and in determining the approach to treatment in acute liver failure.
Cerebral blood flow and metabolism in fulminant liver failure
The depressed cerebral metabolic rate for oxygen in patients with fulminant liver failure is inappropriate to metabolic requirements, as demonstrated by both cerebral lactate production and the increase in cerebral oxygen consumption after improvement in cerebral blood flow.
Use and outcome of liver transplantation in acetaminophen‐induced acute liver failure
Liver transplantation is an effective treatment in a relatively small number of patients with acetaminophen‐induced hepatotoxicity, and for a substantial proportion of patients, transplantation was never an option because of the rapidity of clinical deterioration.
Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia–reperfusion injury
The effect of brief remote ischaemia to the limb in reducing early liver warm IRI is determined.
Maternal and perinatal outcome in severe pregnancy‐related liver disease
The results of this large series suggest a relatively favorable maternal and perinatal outcome in severe AFLP and HELLP syndrome, likely to be achieved through the prevention of the bleeding and infectious complications associated with these disorders.