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A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive programs of gene expression are controlled by variations in motor neuronExpand
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Exercise Stimulates Pgc-1α Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway*
Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that activation of the p38Expand
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Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK
Endurance exercise training promotes mitochondrial biogenesis in skeletal muscle and enhances muscle oxidative capacity, but the signaling mechanisms involved are poorly understood. To investigateExpand
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STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle
It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at theExpand
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Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo *
Adult skeletal muscle fibers can be categorized into fast and slow twitch subtypes based on specialized contractile and metabolic properties and on distinctive patterns of muscle gene expression.Expand
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MEF2 responds to multiple calcium‐regulated signals in the control of skeletal muscle fiber type
Different patterns of motor nerve activity drive distinctive programs of gene transcription in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization amongExpand
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Activation of MEF2 by muscle activity is mediated through a calcineurin‐dependent pathway
Gene expression in skeletal muscles of adult vertebrates is altered profoundly by changing patterns of contractile work. Here we observed that the functional activity of MEF2 transcription factors isExpand
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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively inExpand
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Independent Signals Control Expression of the Calcineurin Inhibitory Proteins MCIP1 and MCIP2 in Striated Muscles
Abstract— Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiacExpand
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Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration* 210
Mammalian skeletal muscles are capable of regeneration after injury. Quiescent satellite cells are activated to reenter the cell cycle and to differentiate for repair, recapitulating features ofExpand
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