R. Williams

Publications615
h-index70
Citations20,786
Highly Influential Citations547
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Simple rules yield complex food webs
Several of the most ambitious theories in ecology describe food webs that document the structure of strong and weak trophic links that is responsible for ecological dynamics among diverse assemblages… Expand
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Flavonoids: antioxidants or signalling molecules?
Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties,… Expand
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Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions
Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment of central sensitization, the spinal cord phenomenon associated with persistent afferent inputs and… Expand
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Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
Ca2+ influx through NMDA receptors can initiate molecular changes in neurones which may underlie synaptic plasticity, neuronal development, survival and excitotoxicity. Signalling through the MAP… Expand
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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production
Altered amyloid precursor protein (APP) processing leading to increased production and oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP processing is regulated… Expand
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SN 1991bg - A type Ia supernova with a difference
We present 13 spectra and 31 photometric observations covering the first 150 days of SN 1991bg in NGC 4374 (M 84). Although SN 1991bg was a type Ia supernova displaying the characteristic Si II… Expand
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CB2 cannabinoid receptors promote mouse neural stem cell proliferation
Neurospheres are clonal cellular aggregates of neural stem/precursor cells that grow in culture as free‐floating clusters. Activation of CB1 cannabinoid receptors, which are expressed by these cells,… Expand
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Neuroinflammation: modulation by flavonoids and mechanisms of action.
Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease.… Expand
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MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage… Expand
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Mg and Ca isotope fractionation during CaCO3 biomineralisation.
The natural variation of Mg and Ca stable isotopes of carbonates has been determined in carbonate skeletons of perforate foraminifera and reef coral together with Mg/Ca ratios to assess the influence… Expand
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