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Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis.
- M. Tagin, C. Woolcott, M. Vincer, R. Whyte, D. Stinson
- Archives of pediatrics & adolescent medicine
- 1 June 2012
Total body cooling and selective head cooling are effective methods in treating newborns with moderate to severe HIE and Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns. Expand
The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
In extremely low birth weight infants, maintaining a higher hemoglobin level results in more infants receiving transfusions but confers little evidence of benefit. Expand
Variations in Practice and Outcomes in the Canadian NICU Network: 1996–1997
Significant variation in NICU practices and outcomes was observed despite Canada's universal health insurance system and is provided for planning research, allocating resources, designing health and public policy, and serving as a basis for longitudinal studies of NICU care in Canada. Expand
Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial.
In extremely preterm infants, targeting oxygen saturations of 85% to 89% compared with 91% to 95% had no significant effect on the rate of death or disability at 18 months. Expand
Transport risk index of physiologic stability: a practical system for assessing infant transport care.
This work used logistic regression to derive a prediction model for mortality within 7 days of NICU admission and develop the Transport Risk Index of Physiologic Stability (TRIPS). Expand
Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants.
Among extremely preterm infants who survived to 36 weeks' postmenstrual age, prolonged hypoxemic episodes during the first 2 to 3 months after birth were associated with adverse 18-month outcomes. Expand
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration
There was no significant difference between a lower SpO2 target range compared with a higher SpO 2 target range on the primary composite outcome of death or major disability at a corrected age of 18 to 24 months. Expand
Improved Outcome of Preterm Infants When Delivered in Tertiary Care Centers
- L. Chien, R. Whyte, K. Aziz, P. Thiessen, D. Matthew, S. Lee
- Obstetrics and gynecology
- 1 August 2001
The results support in‐utero transfer of high‐risk pregnancies to a tertiary level facility because outborn infants were less mature and more ill than inborn infants at NICU admission. Expand
Neurodevelopmental outcome of extremely low-birth-weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.
- R. Whyte
- Seminars in perinatology
- 1 August 2012
No firm conclusion can be reached, other than to report that serious adverse effects may be attributable to one or other of these strategies, that prudent practice is to remain within trial protocols, and that further redesigned clinical trials are required. Expand
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.
- L. Askie, B. Darlow, +4 authors R. Whyte
- The Cochrane database of systematic reviews
- 11 April 2017
When an aligned definition of major disability was used, there was no significant difference in the composite primary outcome of death or major disability in extremely preterm infants when targeting a lower (SpO₂ 85% to 89%) versus a higher (SpOs 91% to 95%) oxygen saturation range. Expand