R. Wesley

Publications10
h-index5
Citations384
Highly Influential Citations13
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Electrokinetic measurements with submicron particles and pores by the resistive pulse technique
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Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum.
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Sizes and concentrations of several type C oncornaviruses and bacteriophage T2 by the resistive-pulse technique
Viruses above about 60 nm in diameter may be rapidly sized to a few nanometers in their natural hydrated state as they pass one by one through a single pore in a newly developed nanometer-particle…
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The origin of crystal-containing cells in the cecal epithelium of mice.
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Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis.
TLDR
It is demonstrated that random transposon mutagenesis uncovers strain improvement-related genes potentially useful for strain engineering.
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An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain
TLDR
The Saccharopolyspora erythraea mutB knockout strain, FL2281, was found to carry a diethyl methylmalonate-responsive (Dmr) phenotype, which represents a new class of strain improvement phenotype and a theory to explain the biochemical mechanism for the Dmr phenotype is proposed.
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Sequential mesenteric lymph node histological response following Trichinella spiralis infection.
TLDR
The histology of mouse secondary lymphoid tissue was examined following infection of Trichinella spiralis, and hyperplasia with concurrent congestion of medullary sinuses and increased numbers of neutrophils, histiocytes, lymphocytes, and eosinophils was detected.
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Biotransformation and recovery of the isoflavones genistein and daidzein from industrial antibiotic fermentations
The objective of this study was to follow the metabolic fate of isoflavone glucosides from the soybean meal in a model industrial fermentation to determine if commercially useful isoflavones could be…
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Application of In Vitro Transposon Mutagenesis to Erythromycin Strain Improvement in Saccharopolyspora erythraea.
TLDR
The in vitro method involves a significant investment in time and effort to create the mutants, but once the mutants are made and screened, a large number of highly relevant mutations of direct interest to erythromycin production can be found.
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SIZES, CONCENTRATIONS, AND ELECTROPHORETIC MOBILITIES OF SUB-MICRON PARTICLES BY THE RESISTIVE PULSE TECHNIQUE
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