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Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.
The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.
This prospective epidemiologic study of SIRS and related conditions provides the first evidence of a clinical progression from SirS to sepsis to severe sepsi and septic shock, and stepwise increases in mortality rates in the hierarchy.
Nosocomial bloodstream infections in United States hospitals: a three-year analysis.
Concurrent surveillance for nosocomial bloodstream infections at 49 hospitals over a 3-year period detected >10,000 infections, and coagulase-negative staphylococci were the most common pathogens on all clinical services except obstetrics, where Escherichia coli was most common.
Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States.
A total of 2340 patients with underlying malignancy were identified among 22,631 episodes of nosocomial bloodstream infections in a prospectively collected database for 49 hospitals in the United States, and the predominant pathogens were coagulase-negative staphylococci.
Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality.
The attributable mortality from nosocomial bloodstream infection is high in critically ill patients and is associated with a doubling of the SICU stay, an excess length of hospital stay of 24 days in survivors, and a significant economic burden.
Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. The National Epidemiology of Mycosis Survey.
Prospective clinical studies are needed to identify which antifungal agents are most protective and which high-risk patients will benefit from antIFungal prophylaxis.
Handwashing compliance by health care workers: The impact of introducing an accessible, alcohol-based hand antiseptic.
Education/feedback intervention and patient awareness programs failed to improve handwashing compliance, however, introduction of easily accessible dispensers with an alcohol-based waterless handwashing antiseptic led to significantly higher handwashing rates among health care workers.
Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities
Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients, and Nosocomial BSI occurred predominantly in very young and/or critically ill children.
Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus.
A program designed to control a widespread outbreak in a university hospital used three surveillance methods to identify the major institutional reservoir of colonized and infected inpatients and found transient carriage on the hands of hospital personnel appears to be the most important mechanism of serial patient-to-patient transmission.
Strategies to Prevent and Control the Emergence and Spread of Antimicrobial-Resistant Microorganisms in Hospitals. A challenge to hospital leadership.
OBJECTIVE To provide hospital leaders with strategic goals or actions likely to have a significant impact on antimicrobial resistance, outline outcome and process measures for evaluating progress