Failure of atriopeptin II to cause arterial vasodilation in the conscious rat.
- R. Lappe, J. Smits, J. A. Todt, J. Debets, R. Wendt
- Biology, MedicineCirculation Research
- 1 April 1985
Data suggest that atriopeptin II infusion markedly attenuated cardiac output in the conscious spontaneously hypertensive rats, and total and regional vascular resistances were increased, possibly through reflex compensatory mechanisms, to maintain arterial pressure in the face of decreased cardiac output.
Effects of fenoldopam on regional vascular resistance in conscious spontaneously hypertensive rats.
- R. Lappe, J. A. Todt, R. Wendt
- Medicine, BiologyJournal of Pharmacology and Experimental…
- 1986
It is indicated that fenoldopam decreased regional vascular resistance in the renal, mesenteric and hindquarters vascular beds of the conscious SHR with the Mesenteric vascular bed demonstrating the greatest reactivity.
Hemodynamic effects of calcitonin gene-related peptide in conscious rats
- R. Lappe, M. Slivjak, J. A. Todt, R. Wendt
- Biology, MedicineRegulatory Peptides
- 1 December 1987
Effects of atrial natriuretic factor on the vasoconstrictor actions of the renin-angiotensin system in conscious rats.
- R. Lappe, J. A. Todt, R. Wendt
- Biology, MedicineCirculation Research
- 1 July 1987
Examining the hemodynamic effects of Wy-47,663, a synthetic human atrial natriuretic factor, in conscious normotensive rats, in renin-dependent (aortic-ligated) hypertensive Rats, and in rats made hypertensive by chronic infusion of angiotensin II found that renal blood flow was reduced and mesenteric vascular resistance was increased markedly in all three groups of rats.
Structural Variants of Verapamil and W‐7 with Combined Ca2+ Entry Blockade/Myosin Phosphorylation Inhibitory Mechanisms
- P. Silver, R. Fenichel, R. Wendt
- Biology, ChemistryJournal of Cardiovascular Pharmacology
- 1 March 1988
Results suggest that these agents possess combined Ca2+ entry blocker/MLC phosphorylation inhibitory mechanisms, which are more vascular specific than verapamil, and are effective inhibitors of intra-cellular Ca2-mediated events in vascular smooth muscle and platelets.
Hemodynamic effects of infusion versus bolus administration of atrial natriuretic factor.
- R. Lappe, J. A. Todt, R. Wendt
- Biology, MedicineHYPERTENSION
- 1 October 1986
The cardiovascular responses to intravenous bolus administration of several synthetic atrial natriuretic peptides were examined in conscious spontaneously hypertensive rats and compared with the hemodynamic effects of continuous infusions of the peptides, indicating that the hemodynamics responses to synthetic atrian peptides are greatly dependent on the mode of administration.
Failure of naloxone to reduce clonidine-induced changes in blood pressure, heart rate and sympathetic nerve firing in cats.
- A. T. Shropshire, R. Wendt
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 March 1983
The results suggest that clonidine reduces blood pressure, heart rate and efferent sympathetic nerve firing in anesthetized normotensive cats by a mechanism independent of an opiate receptor interaction within the central nervous system.
Systemic and coronary vascular effects of the 2- and the 5-mononitrate esters of isosorbide.
- R. Wendt
- Medicine, ChemistryJournal of Pharmacology and Experimental…
- 1 March 1972
The systemic and coronary vascular effects of the 2- and 5-mononitrate metabolites of isosorbide dinitrate (ISDN) were compared to those produced by ISDN and nitroglycerin (GTN) after i.v. and i.a.…
Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat.
- R. H. Meacham, H. W. Ruelius, R. Wendt
- Medicine, ChemistryJournal of Pharmacology and Experimental…
- 1 September 1980
The correlation between concentration in brain and change in blood pressure is in agreement with the predominantly central mechanism of action of guanabenz, and concentrations in plasma were dose related but did not correlate with decreases inBlood pressure.
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