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Failure of atriopeptin II to cause arterial vasodilation in the conscious rat.
The cardiovascular actions of the synthetic natriuretic peptide, atriopeptin II, were examined in conscious unrestrained spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. TheExpand
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Effects of fenoldopam on regional vascular resistance in conscious spontaneously hypertensive rats.
The effects of fenoldopam, a selective dopamine-1 agonist, on regional blood flow and vascular resistance were examined in conscious unrestrained spontaneously hypertensive rats (SHR). Rats wereExpand
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Hemodynamic effects of calcitonin gene-related peptide in conscious rats
The cardiovascular effects of calcitonin gene-related peptide (CGRP) were examined in conscious, unrestrained rats. Changes in mean arterial pressure, heart rate and cardiac output were continuouslyExpand
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Structural Variants of Verapamil and W‐7 with Combined Ca2+ Entry Blockade/Myosin Phosphorylation Inhibitory Mechanisms
Arylalkylsulfonamides, identified as Wy-46,622 and Wy-47,324, combine pharmacological properties of the Ca2+ entry blocker verapamil and the calmodulin antagonist W-7. These agents directly inhibitExpand
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Evaluation of Residential Hot Water Distribution Ssytems by Numeric Simulation
The objective of this project was to evaluate the performance and economics of various domestic hot water distribution systems in representative California residences. While the greatestExpand
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Hemodynamic effects of infusion versus bolus administration of atrial natriuretic factor.
The cardiovascular responses to intravenous bolus administration of several synthetic atrial natriuretic peptides were examined in conscious spontaneously hypertensive rats and compared with theExpand
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Failure of naloxone to reduce clonidine-induced changes in blood pressure, heart rate and sympathetic nerve firing in cats.
An endogenous opiate mechanism may be involved in mediating the hypotensive effects of clonidine. In the cat anesthetized with alpha-chloralose, the effect of naloxone pretreatment on the lowering ofExpand
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Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat.
The antihypertensive agent guanabenz (E-2,6-dichlorobenzylidene aminoguanidine acetate. Wy-8678) was administered i.v. in single doses of 10, 32 and 100 microgram/kg to groups of spontaneouslyExpand
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Aerosol administration of prostaglandins E 1 and E 2 and isoproterenol: studies on the cardiovascular system.
Abstract The systematic vascular and cardiac effects of prostaglandins E 1 and E 2 and isoproterenol were compared after i.v. and aerosol administration in anesthetized intact cats and open-chestExpand
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Systemic and coronary vascular effects of the 2- and the 5-mononitrate esters of isosorbide.
  • R. Wendt
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 March 1972
The systemic and coronary vascular effects of the 2- and 5-mononitrate metabolites of isosorbide dinitrate (ISDN) were compared to those produced by ISDN and nitroglycerin (GTN) after i.v. and i.a.Expand
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