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Failure of atriopeptin II to cause arterial vasodilation in the conscious rat.
Data suggest that atriopeptin II infusion markedly attenuated cardiac output in the conscious spontaneously hypertensive rats, and total and regional vascular resistances were increased, possibly through reflex compensatory mechanisms, to maintain arterial pressure in the face of decreased cardiac output. Expand
Effects of fenoldopam on regional vascular resistance in conscious spontaneously hypertensive rats.
It is indicated that fenoldopam decreased regional vascular resistance in the renal, mesenteric and hindquarters vascular beds of the conscious SHR with the Mesenteric vascular bed demonstrating the greatest reactivity. Expand
Hemodynamic effects of calcitonin gene-related peptide in conscious rats
The cardiovascular effects of calcitonin gene-related peptide were examined in conscious, unrestrained rats and data suggest that CGRP produces a tachycardia through reflex increases in cardiac sympathetic tone and through possible direct positive chronotropic effects on the heart. Expand
Structural Variants of Verapamil and W‐7 with Combined Ca2+ Entry Blockade/Myosin Phosphorylation Inhibitory Mechanisms
Results suggest that these agents possess combined Ca2+ entry blocker/MLC phosphorylation inhibitory mechanisms, which are more vascular specific than verapamil, and are effective inhibitors of intra-cellular Ca2-mediated events in vascular smooth muscle and platelets. Expand
Hemodynamic effects of infusion versus bolus administration of atrial natriuretic factor.
The cardiovascular responses to intravenous bolus administration of several synthetic atrial natriuretic peptides were examined in conscious spontaneously hypertensive rats and compared with the hemodynamic effects of continuous infusions of the peptides, indicating that the hemodynamics responses to synthetic atrian peptides are greatly dependent on the mode of administration. Expand
Failure of naloxone to reduce clonidine-induced changes in blood pressure, heart rate and sympathetic nerve firing in cats.
The results suggest that clonidine reduces blood pressure, heart rate and efferent sympathetic nerve firing in anesthetized normotensive cats by a mechanism independent of an opiate receptor interaction within the central nervous system. Expand
Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat.
The correlation between concentration in brain and change in blood pressure is in agreement with the predominantly central mechanism of action of guanabenz, and concentrations in plasma were dose related but did not correlate with decreases inBlood pressure. Expand
Aerosol administration of prostaglandins E 1 and E 2 and isoproterenol: studies on the cardiovascular system.
The data indicate that, by aerosol, neither the prostaglandins nor isoproterenol invoke cardiovascular responses at doses shown previously to induce significant bronchodilation. Expand
Systemic and coronary vascular effects of the 2- and the 5-mononitrate esters of isosorbide.
  • R. Wendt
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 March 1972
The systemic and coronary vascular effects of the 2- and 5-mononitrate metabolites of isosorbide dinitrate (ISDN) were compared to those produced by ISDN and nitroglycerin (GTN) after i.v. and i.a.Expand
Regional vasodilator actions of calcitonin gene-related peptide in conscious SHR
Data indicate that C GRP is a potent vasodilator peptide in conscious SHR and suggests further that CGRP may contribute to the physiologic regulation of cardiovascular function. Expand