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Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation

Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation Sharmila Dorbala, MD, MPH, Karthik…
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Half-Time SPECT Myocardial Perfusion Imaging with Attenuation Correction

Reducing acquisition time may improve patient throughput, increase camera efficiency, and reduce costs; reducing acquisition time also increases image noise. Newly available software controls the…
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Dynamic SPECT Measurement of Absolute Myocardial Blood Flow in a Porcine Model

Noninvasive measurement of absolute MBF with stationary dedicated cardiac SPECT is feasible using common perfusion tracers using 3 common tracers.
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Optimization of SPECT Measurement of Myocardial Blood Flow with Corrections for Attenuation, Motion, and Blood Binding Compared with PET

Solid-state SPECT provides global MBF and MFR measurements that differ from PET by 2% ± 32% (MBF) and 2%± 28% (MFR).
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New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

This paper will review the recent advancements in radiotracer development for SPECT and PET MPI, autonomic dysfunction, apoptosis, atherosclerotic plaques, metabolism, and viability, and relevant radiochemistry and preclinical and clinical development in addition to molecular imaging with emerging modalities such as cardiac MRI and PET-MR will be discussed.
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Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT

The minimum number of detectable 111In-tropolone-labelled bone-marrow-derived stem cells from the maximum activity per cell which did not affect viability, proliferation and differentiation, and the minimum detectable activity (MDA) of 111In by SPECT are determined.
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Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model

The mouse vena cava IDIF provides repeatable assessment of the blood time–activity curve for Patlak kinetic modeling of rMGU, and an expected significant reduction in myocardial glucose uptake was demonstrated in a type 1 diabetic mouse model, with significant recovery after acute insulin treatment.
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Advances in cardiac SPECT and PET imaging: overcoming the challenges to reduce radiation exposure and improve accuracy.

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Patient position alters attenuation effects in multipinhole cardiac SPECT.

This study evaluated the effects of variable amounts of attenuation as a source is moved within the camera field of view on myocardial SPECT images and found translation of a source relative to a multipinhole camera caused only small changes in homogeneous phantoms with SPS changing <1.5.
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Instrumentation in molecular imaging

  • R. Wells
  • Physics
    Journal of Nuclear Cardiology
  • 12 April 2016
To overcome the limitations of individual modalities, molecular imaging systems often combine individual cameras together, for example, merging nuclear medicine cameras with CT or MRI to allow the visualization of molecular processes with both high sensitivity and high spatial resolution.
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